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Description
GRP94 Recombinant Rabbit mAb (S-R268)Product Specification Host Rabbit Antigen GRP94 Synonyms Endoplasmin, 94 kDa glucose regulated protein (GRP 94), Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog, HSP90B1, TRA1 Location Melanosome Accession P14625 Clone Number S R268 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IP, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | GRP94 |
| Synonyms | Endoplasmin, 94 kDa glucose-regulated protein (GRP-94), Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog, HSP90B1, TRA1 |
| Location | Melanosome |
| Accession | P14625 |
| Clone Number | S-R268 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IP, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | |
| IP | 1:50 | |
| IHC-P | 1:250 | |
| ICC | 1:500 | |
| ICFCM | 1:500 |
Background
GRP94 is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. Grp94 has been shown to be a target for treatment of a plethora of diseases such as glaucoma, multiple myeloma, and metastatic cancer. grp94 includes 5 distinct amino acids in its primary sequence which creates 2 unique sub-pockets, S1 and S2. These sub-pockets have been utilized in current research in order to inhibit the chaperone since its client proteins seem to be up-regulated in cancer cells.
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