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Description
Biotinylated DNAM-1/CD226 His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms DNAM1, CD226, PTA1 Accession Q15762 Amino Acid Sequence Glu19 Asn247, with C terminal 6*His&Avi tag EEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNGGGSHHHHHHGLNDIFEAQKIEWHE Expression System HEK293 Molecular Weight 40 54kDa
Product Specification
| Species | Human |
| Synonyms | DNAM1, CD226, PTA1 |
| Accession | Q15762 |
| Amino Acid Sequence | Glu19-Asn247, with C-terminal 6*His&Avi tag EEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNGGGSHHHHHHGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 40-54kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Koyama M. et al. (2013) Promoting Regulation Via the Inhibition of DNAM-1 After Transplantation. Blood. 121(17):3511-3520. |
Background
DNAX accessory molecule 1 (DNAM-1; CD226) is a costimulatory molecule belonging to the immunoglobulin superfamily. DNAM-1 is primarily expressed on NK and CD8 T cells, which has been shown to enhance the cytotoxic effector function of NK cells and T cells against tumor- and virus-infected cells. DNAM-1 is a member of the Ig superfamily, encoded by a gene on human chromosome 18q22.3, is expressed by human NK cells, T cells, a subset of B cells, monocytes and platelets. Interactions between DNAM-1 on NK cells and its ligands on tumour cells augments the NK cell–mediated cytotoxicity and cytokine production. CD155 and its related family member CD112, the known ligands for DNAM-1, broadly expressed on hematopoietic, epithelial, and endothelial cells. Moreover, it was shown that the interaction of DNAM-1 with CD112 and CD155 contributes to the NK-mediated lysis of both imDCs and mDCs. NK cells also express CD96, which shows only ∼20% homology to DNAM-1 but was also shown to recognize CD155 and promote NK cell adhesion and activation. Decreased NK cell activity has been observed in patients with PDAC, and pancreatic cancer patients have less CD226+ NK cells in the blood than do healthy controls. Dysregulation of DNAM-1 is associated with susceptibility to juvenile idiopathic arthritis, type 1 diabetes (T1D), lupus, and rheumatoid arthritis in patients.
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4.8 ★★★★★
Based on 9 reviews
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Product Reviews
★★★★★ 5
Nice Case & Keyboard
Color: Blue
Love this case with a keyboard. I like using the keyboard vs using one on the screen of iPad. And the keyboard has rechargeable batteries instead of having to buy batteries. And it protects my iPad.
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Reviewed in the United States on May 20, 2026
★★★★★ 1
Beautiful, and everything I want it except that the keyboard keys didn’t work😭
Color: Light Pink
I searched and search for the right keyboard case for me. The most important thing for me was to be able to remove the iPad case itself from the whole case and keyboard, and this one was it. Unfortunately, when I started checking the keyboard a lot of The keys were not output in the correct symbol or letters. So defeats the whole purpose of having a keyboard. I returned it and asked for a replacement, thinking that the item was defected, but when I got the New replacement, it was the same thing so I tried to contact the seller, but there was no option to do that. Therefore, I had to return the second replacement keyboard and look for another keyboard cover.
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Reviewed in the United States on March 23, 2026
★★★★★ 5
Quality and Functional
Color: Navy Blue, Color: Navy Blue
I was looking for a case that could rotate and includes a keyboard. I have the gen 5 Ipad Air and it fits just fine. The part that rotates is magnetic (pretty strong) so if i just want the part with the ipad, I can just take it off. Keyboard is magnetic and the touchpad is such a bonus. It was easy to connect and every key works (can also change light color). Im also really impressed with the quality of the case, its pretty thick and even the plastic is nice. The navy blue color is also super cute, wish they had a dark red color too.
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Reviewed in the United States on May 13, 2026
★★★★★ 5
ABSOLUTELY PERFECT - I LOVE THIS!!!
Color: Pink
I absolutely LOVE this case and the keyboard - it’s absolutely perfect in just about every way. If I had to get nit-picky and find something to give feedback on, I would say it is a bit heavy and it is a bit annoying that you have to move the keyboard forward when you want to use it and backward when you want to close up the case but I don’t care, I love it!
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Reviewed in the United States on March 12, 2026
★★★★★ 5
iPad case
Color: Navy Blue
Great case, functions well and the keyboard is a nice touch. Would recommend.
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Reviewed in the United States on June 3, 2026