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Description
PAM Recombinant Rabbit mAb (SDT-2995-30)Product Specification Host Rabbit Antigen PAM Synonyms Peptidyl glycine alpha amidating monooxygenase Immunogen Synthetic Peptide Location Secreted Accession P19021 Clone Number SDT 2995 30 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample NCI H69, U 2 OS Predicted Reactivity Covering most species Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | PAM |
| Synonyms | Peptidyl-glycine alpha-amidating monooxygenase |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P19021 |
| Clone Number | SDT-2995-30 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | NCI-H69, U-2 OS |
| Predicted Reactivity | Covering most species |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:2000 | Hu |
Background
Peptidylglycine α-amidating monooxygenase (PAM) is a copper-dependent, bifunctional enzyme that catalyzes the C-terminal amidation of peptide hormones and neuropeptides—an essential post-translational modification for their full biological activity—through two sequential catalytic domains, with its expression, localization, and trafficking tightly regulated by alternative splicing, mRNA-binding proteins, and dynamic endocytic recycling, and genetic variants in PAM have been linked to metabolic disorders such as type 2 diabetes and pituitary hormone dysfunction.
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