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Description
CD11c Recombinant Rabbit mAb,PBS Only (SDT-396-48)Product Specification Host Rabbit Antigen CD11c Synonyms Integrin alpha X, CD11 antigen like family member C, Leu M5, Leukocyte adhesion glycoprotein p150 95 alpha chain, Leukocyte adhesion receptor p150 95, ITGAX Immunogen Synthetic Peptide Location Membrane Accession P20702 Clone Number SDT 396 48 Antibody Type Recombinant mAb Application WB, IHC P, IP Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | CD11c |
| Synonyms | Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150/95 alpha chain, Leukocyte adhesion receptor p150/95, ITGAX |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | P20702 |
| Clone Number | SDT-396-48 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:500 | |
| IP | 1:50 |
Background
CD11c, also known as Integrin, is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.
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