SKU: 9316929722

FITC Mouse Anti-Human CD314 (NKG2D) Antibody (S-4154)

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Description

FITC Mouse Anti-Human CD314 (NKG2D) Antibody (S-4154)Product Specification Host Mouse Antigen CD314 (NKG2D) Synonyms NKG2 D type II integral membrane protein; Killer cell lectin like receptor subfamily K member 1; NK cell receptor D; NKG2 D activating NK receptor; D12S2489E; KLRK1 Location Cell membrane Accession P26718 Clone Number S 4154 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation FITC

Product Specification


Host Mouse
Antigen CD314 (NKG2D)
Synonyms NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; D12S2489E; KLRK1
Location Cell membrane
Accession P26718
Clone Number S-4154
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD314, also known as NKG2D (Natural Killer Group 2D), is a type II transmembrane glycoprotein and a member of the C-type lectin-like receptor family that serves as an activating receptor expressed on the surface of natural killer (NK) cells, CD8+ T cells, γδ T cells, and NKT cells. It functions as a homodimeric receptor that recognizes stress-induced ligands, including MICA, MICB, and ULBP1-6 (UL16-binding proteins) in humans, which are upregulated on infected, transformed, or damaged cells due to cellular stress, DNA damage, or viral infection. Upon ligand engagement, NKG2D associates with the adaptor protein DAP10 (DNAX-activating protein of 10 kDa) through a charged transmembrane interaction, triggering phosphoinositide 3-kinase (PI3K)-dependent signaling pathways that promote cytotoxicity, cytokine production, and enhanced immune surveillance. Unlike many other NK cell receptors, NKG2D signaling is not inhibited by self-MHC class I molecules, making it a critical mechanism for distinguishing healthy cells from aberrant cells in the context of cancer immunosurveillance, viral defense, and autoimmune regulation. Dysregulation of the NKG2D-ligand axis has been implicated in various pathological conditions, including tumor immune evasion through ligand shedding or downregulation, as well as autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, highlighting its significance as a therapeutic target in immuno-oncology and immunotherapy development.

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SKU: 9316929722

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MaRee
Chelsea, US
★★★★★ 5
Great Industrial Style Shelf - Easy Install and Sturdy Build
Item Package Quantity: 1, Size: 3 Tiers 24 Inch
I'm really happy with this 3-tier industrial pipe shelf bracket! It fits perfectly with my industrial chic/light steampunk decor theme and adds exactly the vintage industrial look I was going for. Installation: Took me about an hour to get it completely mounted, which was totally reasonable. All the necessary hardware was included, and the instructions were straightforward. I mounted it to drywall without any issues. Quality: The build quality feels solid and sturdy - definitely not flimsy like some wall shelves I've tried. It holds weight as expected, and I have confidence it'll support my display items long-term. Functionality: I'm using it to display various decorative items and knick-knacks, and it's perfect for that purpose. The three tiers give me good display space without taking up floor space. Style: The retro industrial pipe design is spot-on if you're going for that aesthetic. It really complements an industrial chic or steampunk theme well. Overall, I'd definitely recommend this to anyone looking for functional floating shelves with industrial character. Good value for the quality and style you get.
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Reviewed in the United States on September 22, 2025
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Deanna Whitt
Omaha, US
★★★★★ 5
Great product
Item Package Quantity: 1, Size: 2 Tiers 24 Inch, Item Package Quantity: 1, Size: 2 Tiers 24 Inch
Great item. I love the look, it’s perfect for displaying my collection. I didn’t actually set it up per the instructions, I modified it, but it’s like legos, you can get creative. I only attached the top and they hang. Use better fasteners though, I don’t trust the ones they provide
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Reviewed in the United States on April 18, 2026
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Lauren Blaker
Bozeman, US
★★★★★ 5
These are perfect!
Item Package Quantity: 1, Size: 6 Tiers, Item Package Quantity: 1, Size: 6 Tiers
These were a great purchase! I bought two of them, and they look great in my son’s room, as he likes to collect and display action figures. The wood shelves and metal bars are of good quality and are also the perfect size and height. Also excellent value for the price!
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Reviewed in the United States on February 22, 2026
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Edward S.
Grantham, US
★★★★★ 5
Good looking shelf thats fit for purpose
Item Package Quantity: 1, Size: 2 Tiers 24 Inch
Solid and good looking shelf. Very easy to assemble and mount.
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Reviewed in the United States on January 29, 2026
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Timothy M.
Dallas, US
★★★★★ 4
Nice shelves that will work with some modifications
Item Package Quantity: 1, Size: 6 Tiers, Item Package Quantity: 1, Size: 6 Tiers
Pay attention to the bottom shelf and where it is relative to the floor. It’s only about 6 inches, which isn’t good for a retail environment. I swapped the bottom nipples out for some 10” nipples and the results were night and day. So much better now.
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Reviewed in the United States on April 25, 2026

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