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Description
FITC Mouse Anti-Human CD197 Antibody (S-R704)Product Specification Host Mouse Antigen CD197 Synonyms C C chemokine receptor type 7; C C CKR 7; CC CKR 7; CCR 7; BLR2; CDw197; Epstein Barr virus induced G protein coupled receptor 1 (EBI1; EBV induced G protein coupled receptor 1); MIP 3 beta receptor; CMKBR7; EBI1; EVI1; CCR7 Location Cell membrane Accession P32248 Clone Number S R704 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample human peripheral blood
Product Specification
| Host | Mouse |
| Antigen | CD197 |
| Synonyms | C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1; EBV-induced G-protein coupled receptor 1); MIP-3 beta receptor; CMKBR7; EBI1; EVI1; CCR7 |
| Location | Cell membrane |
| Accession | P32248 |
| Clone Number | S-R704 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood lymphocytes |
| Purification | Protein A |
| Concentration | 0.2mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD197, also known as CCR7, is a seven-transmembrane, G-protein-coupled receptor that plays a crucial role in the immune system. It is expressed on activated T cells, B cells, and dendritic cells, and is involved in lymphocyte migration to lymph nodes and the maturation of dendritic cells. CD197 binds to chemokines such as CCL19 and CCL21, which are essential for the interaction between T cells and dendritic cells, thereby linking innate and adaptive immunity. Additionally, its expression is significantly upregulated in B cells infected by the Epstein-Barr virus.
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