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Description
MUC17 Recombinant Rabbit mAb,PBS Only (SDT-1415-49)Product Specification Host Rabbit Antigen MUC17 Synonyms Mucin 17; Small intestinal mucin 3 (MUC 3) Immunogen Recombinant Protein Location Cell membrane Accession Q685J3 Clone Number SDT 1415 49 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt reconstitution,
Product Specification
| Host | Rabbit |
| Antigen | MUC17 |
| Synonyms | Mucin-17; Small intestinal mucin-3 (MUC-3) |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q685J3 |
| Clone Number | SDT-1415-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | |
| IF | 1:500 |
Background
Mucin-17 (MUC17) is a membrane-tethered mucin and a member of the mucin family. Mucin family members play crucial roles in protecting epithelial cells, providing lubrication, maintaining epithelial integrity, aiding in cell adhesion, and offering protection against pathogens, toxins, and foreign particles. MUC17's expression changes have been observed in various pathological conditions, especially in cancer and inflammatory bowel diseases. The biosynthesis of MUC17 occurs in the endoplasmic reticulum of goblet cells and may undergo N-glycosylation either before or after dimerization. In tumor tissues, the abnormal expression of MUC17 is correlated with tumor invasion, metastasis, and prognosis. In recent years, MUC17 has been recognized as an important biomarker for certain cancers and a promising therapeutic target. Particularly, the role of MUC17 in gastric cancer (GC) has attracted researchers' attention. According to one study, MUC17 is highly expressed in gastric cancer tissues and is associated with a favorable prognosis for patients.
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