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Description
Prolactin R/PRLR His Tag Protein, MouseProduct Specification Species Mouse Synonyms Prolactin R, PRLR, PRL R Accession Q08501 Amino Acid Sequence Gln20 Asp229, with C terminal 8*His QSPPGKPEIHKCRSPDKETFTCWWNPGSDGGLPTNYSLTYSKEGEKNTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATNEMGSSTSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWLPPTITDVKTGWFTMEYEIRLKSEEADEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWGQEKSIEIPNDFTLKDGGGSHHHHHHHH Expression System HEK293 Molecular Weight 33 35kDa Purity >95% by SDS PAGE Endotoxin <0.
Product Specification
| Species | Mouse |
| Synonyms | Prolactin R, PRLR, PRL-R |
| Accession | Q08501 |
| Amino Acid Sequence | Gln20-Asp229, with C-terminal 8*His QSPPGKPEIHKCRSPDKETFTCWWNPGSDGGLPTNYSLTYSKEGEKNTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATNEMGSSTSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWLPPTITDVKTGWFTMEYEIRLKSEEADEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWGQEKSIEIPNDFTLKDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 33-35kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Bole-Feysot C. et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-268. |
Background
Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. Knockout prolactin receptor gene (PRL-R) mice are animal models for prolactinomas and PRL acts via autocrine/paracrine inhibiting lactotroph proliferation. Recently, variants of the PRL-R were identified in prolactinoma patients and their frequency was higher compared to individuals from the genomic database. As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. The PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
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4.5 ★★★★★
Based on 14 reviews
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Product Reviews
★★★★★ 5
Incredible!! Looks like a dress shoe, feels like a sneaker
Size: 13, Color: Black
These shoes are amazing. The other comments about comfort are an understatement. I bought these because, although I am a professional working in a business office, I can't bear to wear dress shoes all day so I've always gotten very not-flashy plain black but very comfortable sneakers and hoped for the best in either nobody paying much attention to my shoes or at least not thinking it a big deal. Now I'm off to a business trip meeting with some bigwigs where I'm a bit more self-conscious than usual about the shoes, and I'm thinking either I can get out the dress shoes I own and deal with the discomfort for the week, or see if there is anything like a dress shoe that's actually comfortable. The AI inquiry found these as one of the options, and it was a terrific suggestion. They pretty much look enough like a dress shoe to totally pass when I'll be wearing them with some nice slacks and button-up shirts and blazer. When they arrived earlier today and I laced them up and put them on, these might very well be the most comfortable shoes I've ever had on my feet. I was thinking the Rockport shoes I'd worn maybe 15-20 years ago were the king of the hill for comfort, but I believe these have outdone those. When I put them on and was wearing them around the house to get a feel for them, I really didn't want to take them off. I walk around the house in socks or bedroom slippers, but these shoes are awesome. I've found my everyday shoes to replace the black sneakers I'd been wearing for the past few years that have reached the point where they needed to be retired anyway. When these wear out, I think I'll try another pair from the same manufacturer. I hope their other shoes feel like these. Before asking the AI, I had no idea there were actually "dress sneakers". I described that kind of thing to the AI and just assumed it would find some "passably" comfortable dress shoes, ones that weren't COMPLETELY unconfortable, but this was a great surprise.
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Reviewed in the United States on November 6, 2025
★★★★★ 4
Great look and fit
Size: 10, Color: Brown
Great shoes at a great price. Very comfortable.
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Reviewed in the United States on March 7, 2026
★★★★★ 5
Stylish and Very Comfortable
Size: 9.5, Color: Black
I really liked the design—looks great and feels premium. The insole is very comfortable, soft, and “cloud-like,” making it easy to wear for long periods without discomfort. Definitely a great choice for both style and comfort. ⭐️⭐️⭐️⭐️⭐️
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Reviewed in the United States on April 21, 2026
★★★★★ 5
Must Have Shoe
Size: 12, Color: Brown
Great look shoe, comfortable and a good price. I like this shoe so much I ordered a 2nd pair.
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Reviewed in the United States on June 7, 2026
★★★★★ 5
Worth every penny
Size: 12, Color: Black
Fit is great. Very comfortable
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Reviewed in the United States on May 22, 2026