SKU: 94324844635

Alexa Fluor® 594 Mouse Anti-Human CD279 (PD-1) Antibody (S-R570)

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Description

Alexa Fluor® 594 Mouse Anti-Human CD279 (PD-1) Antibody (S-R570)Product Specification Host Mouse Antigen CD279 (PD 1) Synonyms Programmed cell death protein 1; Protein PD 1; hPD 1; PD1; PDCD1 Location Cell membrane Accession Q15116 Clone Number S R570 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 594 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of

Product Specification


Host Mouse
Antigen CD279 (PD-1)
Synonyms Programmed cell death protein 1; Protein PD-1; hPD-1; PD1; PDCD1
Location Cell membrane
Accession Q15116
Clone Number S-R570
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Purification Protein G
Concentration 0.05mg/ml
Conjugation Alexa Fluor® 594
Physical Appearance Liquid
Storage Buffer PBS, 1% BSA, 0.3% Proclin 300
Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

Programmed cell death protein 1 (PD-1), also known as CD279, is a type I transmembrane protein belonging to the CD28 immunoglobulin superfamily. It is encoded by the Pdcd1 gene and consists of 288 amino acids, including an extracellular IgV-like domain, a transmembrane region, and a cytoplasmic tail. PD-1 is expressed on activated T cells, B cells, macrophages, dendritic cells, and natural killer cells. Its cytoplasmic domain contains two tyrosine residues that form an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM), which play key roles in inhibiting T cell receptor signaling. PD-1 interacts with its ligands PD-L1 and PD-L2 to negatively regulate immune responses, contributing to peripheral tolerance and preventing autoimmune diseases. However, this inhibitory function can also suppress anti-tumor immunity, making PD-1 a promising target for cancer immunotherapy.

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SKU: 94324844635

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4.5 ★★★★★
Based on 15 reviews
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A
Verified Purchase
Amazon Woman
Pawtucket, US
★★★★★ 5
Buy it!!!! It’s great!!!
Color: Blue, Size: 5.5 Inch, Color: Blue, Size: 5.5 Inch
My dog is obsessed with this ball!!! It is very sturdy and he has fun chewing it and playing with it. I bought the biggest size for my mini Goldendoodle. Buy it!! It’s a winner!!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 15, 2026
K
Verified Purchase
Kara
Massapequa, US
★★★★★ 5
Great toy for both inside & outside play!
Color: Pink, Size: 3 Inch, Color: Pink, Size: 3 Inch
My Yorkies love this toy! This is my 3rd purchase of the same type of ball - the small 3" JW Pet HOL-lee ball. I bought one for my first Yorkie, she loved it, so when I got another Yorkie puppy, I bought a 2nd. They play with them so much that they sometimes get left outside. The green one was faded and started to blend it with the grass, so I bought a new one. It's great for a game of fetch, and isneasy to wash. Wish I could select a specific color, as I'd really like a purple one.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 20, 2025
S
Verified Purchase
Solar Meadow
Port Orchard, US
★★★★★ 4
Great indoors and out.
Color: Blue, Size: 4.5 Inch
This is a great toy if your dog likes balls. While it's not my dog's favorite (he favors small squeaky animals) it is safe indoors, soft on floor, walls and furniture and something durable for fetching.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 16, 2026
M
Verified Purchase
MGW
Lowell, US
★★★★★ 5
Terrific for fetch, would not hold up to unmonitored chewing
Color: Colors May Vary, Size: 5.5 Inch
Fabulous for playing fetch. Young crazy-dog enjoys it! Would not hold up to using as a chew toy - we remove it when not playing with the dog.
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Reviewed in the United States on January 13, 2026
L
Verified Purchase
Lg
Lowell, US
★★★★★ 3
Gave my dog an allergic reaction
Color: Blue, Size: 4.5 Inch
I have one that has lasted 2 years of hard play, very durable. However, this newest one in the teal color gave my dog an allergic reaction. Her face and eyes swelled up within 1/2 of playing with it. So I threw it out. I have had no issues with the green one that I bought yesterday ago.
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Reviewed in the United States on January 4, 2026

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