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Description
Prolactin R/PRLR His Tag Protein, HumanProduct Specification Species Human Synonyms Prolactin R, PRLR, PRL R Accession P16471 Amino Acid Sequence Gln25 Asp234, with C terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH Expression System HEK293 Molecular Weight 32 36kDa Purity >95% by SDS PAGE Endotoxin <0.
Product Specification
| Species | Human |
| Synonyms | Prolactin R, PRLR, PRL-R |
| Accession | P16471 |
| Amino Acid Sequence | Gln25-Asp234, with C-terminal 8*His QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 32-36kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Bole-Feysot C. et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-268. |
Background
Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type I cytokine receptor superfamily, and contains two fibronectin type-III domains. Knockout prolactin receptor gene (PRL-R) mice are animal models for prolactinomas and PRL acts via autocrine/paracrine inhibiting lactotroph proliferation. Recently, variants of the PRL-R were identified in prolactinoma patients and their frequency was higher compared to individuals from the genomic database. As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. The PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.
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4.9 ★★★★★
Based on 11 reviews
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Product Reviews
★★★★★ 5
fun for puppy
Style: 8 - Pack Frog
Puppy love them great started toys
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Reviewed in the United States on May 27, 2026
★★★★★ 3
Chew ball and carrot only things to last.
The chew ball is awesome. Lasts forever. The carrot and multicolored rope bone also last and are very durable. The flamingo lasted ten minutes and the stuffing went everywhere quickly, I converted it into a makeshift smaller rope chew, lol. The banana had appeal….but my dogs destroyed it in two days. I liked the banana but it is flimsy. So far I’ve sequestered the Star and “meat” toys, they don’t look to durable.
It’s a cheap product so you get what it’s worth. I wanted a cool flamingo but the flamingo was the easiest for my Brussels Griffon to destroy.
All in all the carrot and chew ball are good but the rest not so much.
Two stars.
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Reviewed in the United States on November 1, 2022
★★★★★ 5
Puppy loved them.
Style: 8 - Pack Frog
My puppy loved them. The bone looks kinda weird though.
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Reviewed in the United States on June 6, 2026
★★★★★ 5
Love
Style: 8 - Pack Frog
Love these this is like our fourth bundle for the price and everything that comes with it is a great deal
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Reviewed in the United States on June 14, 2026
★★★★★ 5
Nice variety and won’t fall apart
Style: 8 - Pack Frog
Great for my puppy to play with, gives a good variety of options and is sturdy enough to not fall apart
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Reviewed in the United States on June 1, 2026