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Description
LILRA4 His Tag Protein, HumanProduct Specification Species Human Synonyms CD85 antigen like family member G, Immunoglobulin like transcript 7, ILT7 Accession P59901 1 Amino Acid Sequence Glu24 Asn446, with C terminal 8*His
Product Specification
| Species | Human |
| Synonyms | CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT7 |
| Accession | P59901-1 |
| Amino Acid Sequence | Glu24-Asn446, with C-terminal 8*His ENLLKPILWAEPGPVITWHNPVTIWCQGTLEAQGYRLDKEGNSMSRHILKTLESENKVKLSIPSMMWEHAGRYHCYYQSPAGWSEPSDPLELVVTAYSRPTLSALPSPVVTSGVNVTLRCASRLGLGRFTLIEEGDHRLSWTLNSHQHNHGKFQALFPMGPLTFSNRGTFRCYGYENNTPYVWSEPSDPLQLLVSGVSRKPSLLTLQGPVVTPGENLTLQCGSDVGYIRYTLYKEGADGLPQRPGRQPQAGLSQANFTLSPVSRSYGGQYRCYGAHNVSSEWSAPSDPLDILIAGQISDRPSLSVQPGPTVTSGEKVTLLCQSWDPMFTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSRSSNPYLLSHPSEPLELVVSGATETLNPAQKKSDSKTAPHLQDYTVENGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 64-73kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Wei Cao, Laura Bover. Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev. 2010 Mar;234(1):163-76. |
Background
LILRA4 (also known as ILT7 and CD85g) encodes a preprotein of 499 amino acids that gives rise to a surface receptor with four extracellular immunoglobulin domains, a transmembrane domain, and a short intracellular tail. The human LILR family of immunoreceptors is found on NK cells, T cells, monocytes, B cells, and dendritic cells. LILRA4 is a negative regulatory receptor that is found on resting pDCs and strongly downregulated after viral or bacterial stimulation. LILRA4 protein directly binds to and can be activated by bone marrow stromal cell antigen 2 (BST2; CD317) protein, the expression of which is found on cells preexposed to IFN or on the surface of human cancer cells. The interaction between ILT7 and BST2 functions to assure an appropriate TLR response by pDCs during viral infection and likely participates in pDC-tumor crosstalk.
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