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Description
Mouse IgG3 Onestep ELISA KitProduct Specification Antigen IgG3 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Ms Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 2. 6% Inter assay: 3. 6% Sample type Cell culture supernatant; Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 0. 198 ng mL Range 0. 78 ng mL 50 ng mL Recovery Cell culture supernatant: 98%
Product Specification
| Antigen | IgG3 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Ms |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 2.6%； Inter-assay: 3.6% |
| Sample type | Cell culture supernatant; Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.198 ng/mL |
| Range | 0.78 ng/mL – 50 ng/mL |
| Recovery | Cell culture supernatant: 98% Serum: 105% Plasma: 105% |
| Assay time | 60 minutes |
| Species reactivity | Ms |
Background
Mouse IgG3 is a unique immunoglobulin subclass with several distinctive properties. Structurally, it has an extended hinge region that confers flexibility but also makes it more susceptible to proteolytic cleavage. A defining feature of IgG3 is its exceptional ability to activate the classical pathway of the complement system, often considered the most potent among all mouse IgG subclasses. However, it binds with very low affinity to most Fc gamma receptors (FcγRs), making it relatively ineffective at FcγR-mediated effector functions like ADCC. IgG3 responses are often prominent against polysaccharide antigens, such as those found in bacterial capsules. It also has a tendency to self-aggregate and form cryoglobulins, especially in certain immune complexes.
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