SKU: 96650037548

Biotin Human Anti-Human CD163 Antibody (OR2805) (S-R740)

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Description

Biotin Human Anti-Human CD163 Antibody (OR2805) (S-R740)Product Specification Host Human Antigen CD163 Synonyms Scavenger receptor cysteine rich type 1 protein M130; Hemoglobin scavenger receptor; M130 Location Secreted, Cell membrane Accession Q86VB7 Clone Number S R740 Antibody Type Recombinant mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 1 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS, 0. 3% Proclin 300

Product Specification


Host Human
Antigen CD163
Synonyms Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor; M130
Location Secreted, Cell membrane
Accession Q86VB7
Clone Number S-R740
Antibody Type Recombinant mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.1 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS, 0.3% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 1μl per million cells in 100μl volume Hu

Background

CD163 is a cysteine-rich scavenger receptor (a member of the SRCR-SF family) encoded by the CD163 gene, primarily expressed on the surface of monocytes and macrophages, with a molecular weight of approximately 130 kDa. Its structure consists of an extracellular domain with nine SRCR domains, a transmembrane segment, and a cytoplasmic tail. CD163 specifically recognizes the hemoglobin-haptoglobin complex (Hb-Hp) and free hemoglobin (FHb), playing a crucial role in hemoglobin clearance and iron metabolism. CD163 exhibits significant immunomodulatory functions by suppressing pro-inflammatory cytokines (e.g., TNF-α, IL-6) and promoting anti-inflammatory factors (e.g., IL-10), thereby mitigating inflammatory responses. It also exerts antioxidant effects through pathways such as HO-1 activation during oxidative stress. The soluble form (sCD163), generated by ectodomain shedding, is elevated in conditions like cirrhosis, diabetes, and rheumatoid arthritis, making it a potential biomarker for inflammatory diseases. Additionally, CD163 serves as the key receptor for porcine reproductive and respiratory syndrome virus (PRRSV), highlighting its importance in veterinary research and disease-resistant breeding strategies.

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SKU: 96650037548

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Reviewed in the United States on March 15, 2026
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