SKU: 96825733502

ROBO1 Recombinant Rabbit mAb (S-2931-169)

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Description

ROBO1 Recombinant Rabbit mAb (S-2931-169)Product Specification Host Rabbit Antigen ROBO1 Synonyms Roundabout homolog 1; Deleted in U twenty twenty; H Robo 1; DUTT1 Immunogen Synthetic Peptide Location Cell membrane Accession Q9Y6N7 Clone Number S 2931 169 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HepG2, PANC 1, HeLa, BxPC 3, A549, U 2 OS, mouse E14 embryo, rat E14 embryo Purification Protein A Concentration 0. 5 mg ml

Product Specification


Host Rabbit
Antigen ROBO1
Synonyms Roundabout homolog 1; Deleted in U twenty twenty; H-Robo-1; DUTT1
Immunogen Synthetic Peptide
Location Cell membrane
Accession Q9Y6N7
Clone Number S-2931-169
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample HepG2, PANC-1, HeLa, BxPC-3, A549, U-2 OS, mouse E14 embryo, rat E14 embryo
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
IHC-P 1:500 Hu
ICC 1:500 Hu

Background

ROBO1 is a ~165 kDa single-pass transmembrane receptor of the immunoglobulin superfamily whose extracellular region contains five Ig-like domains and three fibronectin repeats that bind the secreted SLIT1/2 ligands, while its cytoplasmic tail carries four conserved CC motifs (CC0-CC3) that recruit adaptors such as srGAPs, Ena/VASP and DCC to transduce repulsive or attractive signals regulating axon guidance at the CNS midline, neuronal precursor migration, angiogenesis and even tumor metastasis by modulating Rho-family GTPases and actin cytoskeleton dynamics.

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SKU: 96825733502

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