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Description
CD300b/LMIR5/CD300LB Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD300b Protein, Human; CLM 7 Protein, Human; CLM7 Protein, Human; CMRF35 A2 Protein, Human; IREM 3 Protein, Human; IREM3 Protein, Human; TREM 5 Protein, Human; TREM5 Protein, Human Accession AAH28091 Amino Acid Sequence Ile55 His187, with C terminal hIgG1 Fc Expression System HEK293 Molecular Weight 48 53kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag
Product Specification
| Species | Human |
| Synonyms | CD300b Protein, Human; CLM-7 Protein, Human; CLM7 Protein, Human; CMRF35-A2 Protein, Human; IREM-3 Protein, Human; IREM3 Protein, Human; TREM-5 Protein, Human; TREM5 Protein, Human |
| Accession | AAH28091 |
| Amino Acid Sequence | Ile55-His187, with C-terminal hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 48-53kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Journal List Cell Death Differ v.21(11); 2014 Nov PMC4211373. |
Background
The CD300 receptor family members are a group of molecules that modulate a variety of immune cell processes. The CD300 receptor family consists of members with activating and inhibitory capabilities mainly expressed on the surface of immune cells. LMIR5, also known as CD300b, CD300LB, CLM-7, and IREM‑3, is a glycoprotein member of the immunoglobulin superfamily. Human LMIR5 consists of a 134 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain, a 21 amino acid (aa) transmembrane segment, and a 29 aa cytoplasmic domain. Studies have shown that CD300b recognizes PS as a ligand and regulates phagocytosis of apoptotic cells through DAP12 signaling pathway.
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