SKU: 97607853621

ADAM8 Recombinant Rabbit mAb (S-2546-23)

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Description

ADAM8 Recombinant Rabbit mAb (S-2546-23)Product Specification Host Rabbit Antigen ADAM8 Synonyms Disintegrin and metalloproteinase domain containing protein 8; Cell surface antigen MS2; CD156a; MS2 Immunogen Recombinant Protein Location Membrane Accession P78325 Clone Number S 2546 23 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample MDA MB 231, Capan 1, BxPC 3 Purification Protein G Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance

Product Specification


Host Rabbit
Antigen ADAM8
Synonyms Disintegrin and metalloproteinase domain-containing protein 8; Cell surface antigen MS2; CD156a; MS2
Immunogen Recombinant Protein
Location Membrane
Accession P78325
Clone Number S-2546-23
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu
Positive Sample MDA-MB-231, Capan-1, BxPC-3
Purification Protein G
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu

Background

ADAM8 (a disintegrin and metalloproteinase domain 8), also designated CD156a, is a type-I transmembrane metalloproteinase encoded at 10q26.3 that belongs to the ADAM family of cell-surface sheddases; its modular architecture comprises a pro-domain, catalytic metalloprotease, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic tail domains, endowing it with the dual capacity to cleave extracellular-matrix proteins such as fibronectin and collagen while simultaneously regulating cell–cell and cell–matrix interactions through its disintegrin motif. Physiologically, ADAM8 is expressed at highest levels in immune and neuronal tissues, where it modulates leukocyte transmigration, cytokine and chemokine shedding (e.g., TNF-α, CX3CL1), and neuronal adhesion during development and repair; pathologically, its marked up-regulation in cancers promotes epithelial-to-mesenchymal transition, angiogenesis, and metastasis by attenuating intercellular adhesion and degrading matrix barriers, and in allergic asthma it orchestrates airway remodeling and hyper-responsiveness, rendering ADAM8 a prognostic biomarker and an attractive therapeutic target for anti-metastatic and anti-inflammatory interventions .

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SKU: 97607853621

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4.3 ★★★★★
Based on 26 reviews
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machon e.
Draper, US
★★★★★ 5
Almost indestructible
Color: Mixed Blue
So far my toy destroying pup hasn't destroyed this one. He tears Kong toys up in hours. Does it look pretty no lol ita been buried and thrown and chewed for months.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2026
B
Verified Purchase
Bob Hammett
Dallas, US
★★★★★ 1
Not for aggressive chewers
Color: Mixed Blue
I purchased 2. The Rubber in the middle was chewed through in an hour by american bullys. Not for aggressive chewers. They are not interested in them anymore.
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Reviewed in the United States on June 6, 2026
D
Verified Purchase
Dave A.
Pawtucket, US
★★★★★ 3
Harder and heavier than a dog toy should be, but it is sturdy.
Color: Mixed Blue
The outer rim is a very hard plastic, hard enough to dent and ding furniture. Too hard to throw in the house. Dog likes it but has difficulty getting his mouth around the sides as the item is very heavy for its size. Squeaker in the middle was a a nice surprise. Would not buy again.
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Reviewed in the United States on June 7, 2026
V
Verified Purchase
Vicky Courtright
Natrona Heights, US
★★★★★ 4
Durable and well made.
Color: Mixed Blue
Our dog will chew any toy up in 2.5 seconds. This has lasted for quite some time. It's super hard which can be a downfall because they lose interest. Squeeker is hard to push down but overall it's outlasted other toys.
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Reviewed in the United States on April 27, 2026
S
Verified Purchase
shelly
Grantham, US
★★★★★ 5
Dog toy
Color: Mixed Blue
Glad I bought this. My dog job is to destroy her toys or she thinks so. This is great for her chewing and catching while it will be sometime before she destroys this one
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Reviewed in the United States on May 24, 2026

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