SKU: 98976281071

CD40/TNFRSF5 His Tag Protein, Cynomolgus

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Description

CD40/TNFRSF5 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50 Accession G7PG38 Amino Acid Sequence Glu21 Arg193, with C terminal His Expression System HEK293 Molecular Weight 26 33kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after

Product Specification


Species Cynomolgus
Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Accession G7PG38
Amino Acid Sequence Glu21-Arg193, with C-terminal His
Expression System HEK293
Molecular Weight

26-33kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1、van Kooten C. et al. (2000) CD40-CD40 ligand. J Leukoc Biol. 67(1): 2-17.

2、Bhushan A. et al. (2002) CD40: CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24(3): 311-324.

3、Chatzigeorgiou A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-483.

4、Li R. et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-3917.

Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Both CD40 and CD40 L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing. CD40 and CD40L are widely expressed in various types of cells, among which B cells and myeloid cells constitutively express high levels of CD40, and T cells and platelets express high levels of CD40L upon activation. CD40L self-assembles into functional trimers which induces CD40 trimerization and downstream signaling. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate. The mechanisms of benefits include immune cell activation and tumor cell lysis/apoptosis in malignancies, or immune cell inactivation in autoimmune diseases and allograft rejection.

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SKU: 98976281071

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4.8 ★★★★★
Based on 29 reviews
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K
Verified Purchase
KS
Bozeman, US
★★★★★ 5
Great watch. New model lacks holographic diffraction membrane on the display.
Color: Black
It's a really cool design. It's lightweight, thin, easy to read, and feels well made. I do not find the buttons hard to press. Setting the time is easy. In the showcase video of this watch it clearly has a holographic diffraction membrane on the display, which is what gives it the green reflection as the watch spins around, but that is the older model with the "Atlantis 100" writing on the 12 o'clock position. This new model does not have the holographic diffraction membrane, and that is a bit of a let down for me personally. It was a design feature that really set the watch apart from most other digital watches. It's something to keep in mind if you owned the older model and expect the new one to be exactly the same.
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Reviewed in the United States on September 24, 2025
A
Verified Purchase
Adrian L.
Louisville, US
★★★★★ 5
$30 well spent
Color: Black, Color: Black
I haven't worn a digital watch in years. I have a Seiko automatic I wear to work events or anything where I feel like having a "dress" watch (it's not really a dress watch, but just a nice watch) but otherwise, basically rely on my cell phone for telling time and setting alarms. Recently, I've suddenly become interested in digital watches again. I remember how cool the Indiglo feature was on watches as a kid in the early 90s and started researching and comparing. I ended up purchasing one of the $99 Casio G-Shock watches with the solar and atomic clock radio features, and while it's definitely very cool, the wide square shape of the watch face and the curved resin wristband isn't comfortable for me to wear all day. So then I saw this one and figured for $30, it was worth giving it a shot. And I'm glad I did. First of all, the watch is very comfortable to wear all day -- which really should be the most important thing. I don't have super big wrists but also have had issues in the past with wrist sprains and mild tendinitis from typing all day at work and then painting and repairing my home on the evenings and weekends. The small, round watch face is very comfortable and sits well on my wrist. The band is admittedly very cheap and flimsy feeling, but again, $30 watch. I don't particularly care for stopwatch, timer, or alarm features from a digital wrist watch, but the Indiglo is so cool. Casio has stopped using electroluminescence in its watches and newer G-Shocks and similar Casios have a small LED that looks like the crappy old lights in cheaper digital watches from the 80s and 90s. It's disappointing to spend $100 on a new G-Shock to find out that the EL feature has been retired. However, this $30 Timex that feels more comfortable, fits better, and seems to be just as durable, has it.
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Reviewed in the United States on October 23, 2021
R
Verified Purchase
Roberto
West Palm Beach, US
★★★★★ 4
Very good looking accurate watch but,
Color: Black
As others have said buttons very hard to operate. I'm not sure if it's by design or if they released an abnormally tough run, but they do require intent and strength to push. On the bright side, you'll never (and I repeat NEVER) accidentally press the button and activate something. You have to try hard to push them intentionally, I don't think it's even possible to accidentally press one. The look and feel of the watch are great though and I think the band is actually better quality than most Casio bands. Overall the price increase over similar casios gets you - better light, nice slim profile, and a better band, as well as buttons that won't accidentally push (because they're so tough to lol)
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2024
W
Verified Purchase
WT
Birmingham, US
★★★★★ 1
Defective watch - after 1.5 months of use, time automatically reset every day
Color: Teal/Brown
I'd only had the watch for about 1.5 months before the time started to automatically reset without any apparent reason. I would set it to the correct time, then before the day was done, I would look down and see that the watch time was drastically incorrect. I've seen at least one other review on Amazon describing this same problem with the Atlantis. Other than that, as other reviewers have mentioned, the buttons are a bit hard to press but that isn't a dealbreaker in my opinion (you get used to it). If you like the way the watch looks, and want a simple, smaller, lightweight digital watch, the Atlantis is adequate, especially at this price point - assuming it's not defective like mine.
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Reviewed in the United States on January 24, 2024
B
Verified Purchase
Bobbie and Chuck F
Los Angeles, US
★★★★★ 3
It’s an “OK” watch.
Color: Black
I just received this watch. The watch fits well and is comfortable, light weight and is thinner than others I have had, which I actually like. There is no manual and trying to find one on line is a tall order. I just fiddled around with it to figure it out. Still working on some of the features. It apparently has two time settings which is good if you travel to other time zones without having to reset your time. Just hit the button. Speaking of the buttons, they are pretty tough to push. The display is so-so; some may have difficulty reading it although the numbers for the time are larger. It’s a decent watch but being worth $42 remains to be seen. I was a bit unhappy to receive the watch in an Amazon paper bag envelope. The box was crushed but the watch was in tact. It really should have been shipped in a box.
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Reviewed in the United States on March 12, 2022

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