SKU: 99208699615

Lymphocyte antigen 75/CD205 Recombinant Rabbit mAb (S-2707-25)

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Description

Lymphocyte antigen 75/CD205 Recombinant Rabbit mAb (S-2707-25)Product Specification Host Rabbit Antigen CD205 Synonyms Lymphocyte antigen 75; Ly 75; C type lectin domain family 13 member B; DEC 205; gp200 MR6; CLEC13B; LY75 Immunogen Recombinant Protein Location Membrane Accession O60449 Clone Number S 2707 25 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample THP 1, Daudi Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance

Product Specification


Host Rabbit
Antigen CD205
Synonyms Lymphocyte antigen 75; Ly-75; C-type lectin domain family 13 member B; DEC-205; gp200-MR6; CLEC13B; LY75
Immunogen Recombinant Protein
Location Membrane
Accession O60449
Clone Number S-2707-25
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample THP-1, Daudi
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:1000 Hu

Background

CD205, also known as DEC205 or LY75, is a ~205 kDa type I transmembrane glycoprotein belonging to the macrophage mannose receptor family of C-type lectins; it contains an N-terminal cysteine-rich domain, a fibronectin type II repeat, ten tandem C-type lectin-like carbohydrate-recognition domains, a single transmembrane segment and a short cytoplasmic tail harboring the tyrosine-based “FERN” and “DIEEV” endosomal sorting motifs that drive constitutive clathrin-mediated internalization and recycling to late endosomes/MHC class II compartments. Predominantly expressed on CD8α⁺ dendritic cells, thymic epithelial cells and certain B subsets, CD205 functions as a pattern-recognition receptor that binds apoptotic/necrotic cells, selected glycoproteins and CpG-rich nucleic acids, enabling efficient capture, processing and cross-presentation of antigens for initiation of CD8⁺ T-cell immunity; this property has made it a premier target for receptor-directed vaccination strategies in which antigens are fused to anti-CD205 antibodies to elicit potent, antigen-specific tolerance or protective responses. In addition, CD205 participates in peripheral T-cell deletion, central tolerance through negative selection in the thymus, and has been implicated in autoimmune diseases, tumor immunosurveillance and metastasis, with its expression levels correlating with prognosis in several cancers, thereby serving as both a biomarker and a therapeutic gateway in immunotherapy.

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Exchange/Return Notes
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SKU: 99208699615

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timothy scalabrelli
Natrona Heights, US
★★★★★ 4
Comfortable
Size: 9, Color: Black/Ivory
Most comfortable and roomy shoes I ever wore. Great for insoles. Looks nice too. The base of the shoe is a bit too thick but it’s fine.
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Reviewed in the United States on September 5, 2025
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David F.
Massapequa, US
★★★★★ 5
Great looking shoes. Can’t beat Cole Hahn
Size: 11.5, Color: Optic White/Navy Blazer/Optic White
Great looking shoes and very comfortable. I had to go down 1/2 a size from 12 to 11 1/2. I would recommend them 💯%.
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Reviewed in the United States on June 6, 2026
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Orlando A.
Chelsea, US
★★★★★ 5
Excelente producto
Size: 8.5, Color: Navy Blazer/British Tan/Ivory
Las tallas pueden ser muy pequeñas par la talla real puede ser la orma del zapato
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Reviewed in the United States on May 23, 2026
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Clinton
West Palm Beach, US
★★★★★ 5
Fit
Size: 10.5, Color: Optic White/Navy Blazer/Optic White
Fits snug and looks good
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Reviewed in the United States on May 4, 2026
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CesarGPhoto
Dallas, US
★★★★★ 5
Absolutely great
Size: 10, Color: Navy Blazer/British Tan/Ivory
Bought these for an Italy trip to dress up in a dressy casual style. Walked 20k+ steps daily in these for 13 days straight and my feet were comfortable all day long. Highly recommended.
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Reviewed in the United States on April 11, 2026

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