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Description
CHOP Recombinant Mouse mAb (S-3924)Product Specification Host Mouse Antigen CHOP Synonyms DNA damage inducible transcript 3 protein; DDIT 3; C EBP zeta; C EBP homologous protein (CHOP); C EBP homologous protein 10 (CHOP 10); CCAAT enhancer binding protein homologous protein; Growth arrest and DNA damage inducible protein GADD153; CHOP; CHOP10; GADD153; DDIT3 Location Cytoplasm, Nucleus Accession P35638 Clone Number S 3924 Antibody Type Mouse mAb Isotype IgG2a Application WB, ICC
Product Specification
| Host | Mouse |
| Antigen | CHOP |
| Synonyms | DNA damage-inducible transcript 3 protein; DDIT-3; C/EBP zeta; C/EBP-homologous protein (CHOP); C/EBP-homologous protein 10 (CHOP-10); CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA damage-inducible protein GADD153; CHOP; CHOP10; GADD153; DDIT3 |
| Location | Cytoplasm, Nucleus |
| Accession | P35638 |
| Clone Number | S-3924 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Tunicamycin treated HeLa |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
CHOP (C/EBP homologous protein) is a 29 kDa, 169-amino-acid bZIP transcription factor whose basic DNA-binding region carries two disruptive proline substitutions that enable it to form non-DNA-binding heterodimers with other C/EBP or ATF4 partners, thereby acting as a dominant-negative repressor of many C/EBP target genes while also partnering with ATF4 to transcriptionally activate pro-apoptotic genes such as GADD34, BIM, DR5 and TRB3, leading—after phosphorylation by p38 MAPK at Ser78/81 and JNK-mediated enhancement—to mitochondrial outer-membrane permeabilization, cytochrome-c release, caspase activation and endoplasmic-reticulum-stress-induced apoptosis.
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4.6 ★★★★★
Based on 1860 reviews
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Product Reviews
★★★★★ 5
Great Read!!! Great story!!!
Format: Kindle
The series is long, but Ms. Wolfhart does a fantastic job of weaving this tale while bringing so much to the characters. Surprises and plot twists along the way to keep you intrigued. There is some graphic sex, but is no way the focal point. Grammar was excellent (a rare find with a lot of self publishers) with only a few noted errors. I rarely give 4 stars, let alone 5.
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Reviewed in the United States on April 30, 2021
★★★★★ 3
Sadly, DNF
Format: Kindle
I read this thru KU. I LOVED the synopsis. And then I began reading... and it was a DNF at 68% after picking it up and putting it down several times because I really loved the main female character.
*****SPOILERS*****
Pros:
The world is unique, intriguing and fun. The primary female character is bad-a** but not a b*tech or a mary sue. The primary female has depth. I really want to know what happens to her even tho it's been weeks and I don't remember her name. The villains to the point I read are pretty good -- an ever present threat of mysterious and possibly many culprits.
Cons:
Way, way too many points of view. I stopped counting at 7. It's the prime reason why I don't care about most of the characters or remember their names even when I like them. There's just too many points of view so almost none of the characters have enough book space for the author to properly develop them. This literally killed the book for me. Actually it killed my desire to read. For weeks.
The main male is more villain than hero. He agreed to marry the main female then locks her up & eschews her for her sister, all while bad mouthing her as unfit to rule when he never spent any time with her getting to know her. He is actually unfit to rule as he is blind to the woes of his own kingdom and starts off a peace mission to secure a ceasefire through marriage by murdering an inn full of people in her country for no real reason. Plus, he constantly makes promises he does not keep. And it's gross of him to pine for the sister behind the main female's back.
*****
As much as I really wanted to see what happened to the main female character, it wasn't enough for me to keep trying to slog thru this book. There was a lot of potential here that just fell short.
Hence, 3 stars.
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Reviewed in the United States on June 19, 2021
★★★★★ 5
Fae Courts with High Intrigue
Format: Kindle
This book is one that just builds and builds and then surprises you to no end. You may think you know the villains and then you are jolted in another direction. Princess Reyna is a real gem, strong of character, a fierce fighter, and loyal to her family and kingdom. Just when you think she and Lorcan, well you know, the plot is flipped. Can't wait to see where this goes in book two.
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Reviewed in the United States on July 7, 2023
★★★★★ 4
Slow, sorry but good
Format: Kindle
This was a slow moving book. Lots of character pov chapters, lots of superfluous descriptions and endless courtly appearances stalled this book to start. Once you get into the heart of the story, it takes off. Before you know it the book is done. My favorite character is Reyna. She is so strong. She is true to herself. She gets into a lot of trouble with her headstrong ways but it's entertaining. I have high hopes for Lorcan. He is honorable to a fault. Thane had turned out to be better than I thought but i still don't like him. Eislin is useless. Great plot twists at the end. I'm looking forward too book 2.
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Reviewed in the United States on June 6, 2020
★★★★★ 5
Very detailed! Beautiful world building! Strong Heroine!
Format: Kindle
Starts off a little slow and confusing with different POV’s, but starts to all come together towards the middle to make an elaborate plot line and makes it all worth it. Beautiful world building and attention to detail as well as great writing. The cliffhanger was gut wrenching! Can’t wait for the next book!
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Reviewed in the United States on March 4, 2020