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Description
Equine CD4 Mouse mAb (S-1378-25)Product Specification Host Mouse Antigen Equine CD4 Synonyms T cell surface glycoprotein CD4; T cell surface antigen T4 Leu 3 Immunogen Recombinant Protein Location Cell membrane Accession F6Y6X8 Clone Number S 1378 25 Antibody Type Mouse mAb Isotype IgG2a,k Application ELISA Reactivity Hr Purification Protein A Concentration 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | Equine CD4 |
| Synonyms | T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | F6Y6X8 |
| Clone Number | S-1378-25 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | ELISA |
| Reactivity | Hr |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Background
CD4 is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR) and is found on the surface of immune cells such as helper T cells, monocytes, macrophages, and dendritic cells. It is a member of the immunoglobulin superfamily and has four immunoglobulin domains (D1 to D4) that are exposed on the extracellular surface of the cell. The D1 domain of CD4 interacts with the β2-domain of MHC class II molecules, allowing T cells displaying CD4 to be specific for antigens presented by MHC II. The cytoplasmic tail of CD4 contains a sequence of amino acids that allow it to recruit and interact with the tyrosine kinase Lck, which is crucial for T cell activation. CD4 is also the receptor for HIV, which uses the protein to gain entry into host T-cells through its viral envelope protein gp120.
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