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Description
PXR Recombinant Rabbit mAb (S-2398-43)Product Specification Host Rabbit Antigen PXR Synonyms Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor (SXR); NR1I2 Immunogen Synthetic Peptide Location Nucleus Accession O75469 Clone Number S 2398 43 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HeLa, HepG2, THP 1, mouse liver, rat liver
Product Specification
| Host | Rabbit |
| Antigen | PXR |
| Synonyms | Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor (SXR); NR1I2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | O75469 |
| Clone Number | S-2398-43 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HepG2, THP-1, mouse liver, rat liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
PXR protein (Pregnane X Receptor) is a nuclear receptor that plays a crucial role in the regulation of drug metabolism and detoxification processes in the body. It is primarily expressed in tissues such as the liver and intestines. When activated by various endogenous and exogenous compounds, including certain drugs, PXR can induce the expression of numerous target genes. These target genes are involved in the production of enzymes like cytochrome P450, which are key for the biotransformation of drugs and other xenobiotics. This helps the body to effectively metabolize and eliminate potentially harmful substances. PXR's activity is important for maintaining homeostasis and ensuring the proper functioning of the body's detoxification systems.
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