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Description
Alexa Fluor 647-Labeled Her2 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD340,ERBB2,NEU,NGL,MLN19,TKR1 Accession P04626 1 Amino Acid Sequence Thr23 Thr652 with hIgG1 Fc Tag at C Terminus Expression System HEK293 Molecular Weight 110 120kDa (Reducing) Conjugation Alexa Fluor 647 Tag Human IgG1 Fc Physical Appearance Liquid Storage Buffer PBS 7. 4 Stability & Storage 12 months from date of receipt stored at 20 to 80. 1 week, 2 to 8 under sterile conditions Recommend to aliquot
Product Specification
| Species | Human |
| Synonyms | CD340,ERBB2,NEU,NGL,MLN19,TKR1 |
| Accession | P04626-1 |
| Amino Acid Sequence | Thr23-Thr652 with hIgG1 Fc Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 110-120kDa (Reducing) |
| Conjugation | Alexa Fluor® 647 |
| Tag | Human IgG1 Fc |
| Physical Appearance | Liquid |
| Storage Buffer | PBS 7.4 |
| Stability & Storage |
· 12 months from date of receipt stored at --20 to -80℃. · 1 week, 2 to 8℃ under sterile conditions · Recommend to aliquot the protein into smaller quantities for optimal storage. · Please avoid repeated freeze-thaw cycles.
|
| Reference | 1、Krawczyk N. et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-4024. |
Background
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
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