SKU: 4566122984

S23 – Solution, 600MG (20mg/mL)

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Description

S23 – Solution, 600MG (20mg/mL)S23 S23 is an orally available selective androgen receptor modulator (SARM). Originally developed by GTX Inc. as a form of hormonal contraception for men, it exhibits a high affinity for the androgen receptor, with a Ki value of 1. 7 nM. A study published by Jones et al. compared the effectiveness of S23 in both castrated and intact male rats. Effects of S23 on Fertility In castrated male rats, the effective dose of S23 in the prostate was 0. 43 mg

S23

S23 is an orally available selective androgen receptor modulator (SARM). Originally developed by GTX Inc. as a form of hormonal contraception for men, it exhibits a high affinity for the androgen receptor, with a Ki value of 1.7 nM. A study published by Jones et al. compared the effectiveness of S23 in both castrated and intact male rats.

Effects of S23 on Fertility

In castrated male rats, the effective dose of S23 in the prostate was 0.43 mg/day, and 0.079 mg/day in the levator ani muscle. In intact male rats, a dose higher than 0.1 mg/day resulted in a suppression of luteinizing hormone (LH) by more than 50%. This dose corresponded with a reduction in prostate size and an increase in the size of the levator ani muscle.

In a study involving intact male rats subjects treated with both S23 and estradiol benzoate (to maintain sexual behavior), no sperm was found in the testes of four out of the six subjects after 10 weeks. Moreover, none of the six subjects reported a pregnancy. Following treatment, infertility was completely reversible; all subsequent mating trials resulted in pregnancy.

Effects of S23 on Muscle Mass and Body Fat

S23 exhibits effects on muscle mass and body fat that are similar to those of anabolic steroids. Research involving male rats revealed that treatment with S23 led to a reduction in total body weight and fat mass. Rats in this study were also administered estradiol benzoate to maintain sexual behavior. Despite the known muscle loss effects of estrogens, the combination with S23 neutralized this effect, resulting in an increase in muscle mass in the male rats.

Additionally, another study indicated that S23 might be effective against muscle loss caused by prolonged use of glucocorticoids. This research also looked at the effects of S23 on muscle atrophy induced by castration. In both scenarios, muscle loss was observed, but the administration of S23 and testosterone blocked the dexamethasone-induced dephosphorylation of Akt. The findings suggest that S23 could be an effective treatment against muscle loss induced by glucocorticoids.


concentration
20mg/ml.

half-life
12 hours

DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary use. Please use with our DISCLAIMER before ordering.

 

Data sheet

S-23 – Solution, 600mg (20mg/mL)

Application Selective Androgen Receptor Modulator
CAS 1010396-29-8
Molar Mass 416.753 g/mol
Chemical Formula C18H13ClF4N2O3
IUPAC Name (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide
Synonyms UNII-XDK89456WM, 3-(4-cyanophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide, CCTH-methylpropionamide
Storage Room Temperature
Solubility Soluble in PEG400, Ethanol
Organoleptic Profile Clear liquid
Physical Form Solution in PEG400
Specification 20mg/mL ±5%
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our disclaimer prior to ordering.
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SKU: 4566122984

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T. Eisen
Fort Morgan, US
★★★★★ 5
Love the Simpsons!
Format: Paperback
I buy these to give to my nephews, but not before I read them first! LOL!
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Reviewed in the United States on May 11, 2020
M
Verified Purchase
mwreview
Charlottesville, US
★★★★★ 4
Not Quite Up to Simpsons Comics Standards, but Still Fun
Format: Paperback
Despite the cover, there is no western-related comic in this book (probably a good thing). This comic book is funny (it includes a comic book convention survival guide and a look at Lisa's dream house), but Matt Groening and company really raised the bar with some of their other comic books-hence the four star grade. "Krustonia"-Krusty starts his own utopian nation to avoid paying income taxes. Sounds like something he'd do. "Flanders' Big Score"-Fun-diddly-fun comic where amateur detective Ned Flanders investigates the case of the missing church fund-raiser money. "Let's Get Ready to Bumble"-Homer becomes a professional wrestler. Not as good as the other comics in this book. "Bringing Down Baby"-Short starring Maggie which also includes the infamous baby with the one eyebrow. Only mildly amusing. "Smitherses!"-The nuclear power plant employees are on strike for a 5 cent per year raise. True to form, Mr. Burns decides that the best solution is to clone a staff of devoted sycophants (i.e. Smitherses). When the Smitherses begin to compete for Mr. Burns' attention-Watch out! This is a funny, imaginative comic. "Bore Us the Movie Gruel"-Bart and company watch a 1950s film starring Troy McClure (how old is this guy?) and a mule. The usual sarcastic comments are offered. "Radioactive Homer"-A complicated comic. The gist of it is that Homer believes he is Radioactive Man and joins forces with Leon (insane asylum inmate "Michael Jackson" in the TV episode "Stark Raving Dad") to take down Mr. Burns' "Project Q" (mentioned in Simpsons Comics #1 in the Extravaganza book). Has a very funny ending.
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Reviewed in the United States on December 22, 2002
W
Charlottesville, US
★★★★★ 5
Matt Groening
Format: Paperback
i want matts autograph
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Reviewed in the United States on February 1, 1999
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david shen
Port Orchard, US
★★★★★ 1
Terrible condition!!! not readable. what a shame!
Format: Paperback
Terrible condition!!! not readable. what a shame!
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Reviewed in the United States on May 30, 2022
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Mike Reed
Dallas, US
★★★★★ 3
Krustonia
Format: Paperback
This was an okay book, with nothing exceptional. Starting the book off with "Krustonia" was a big mistake, as it's easily the worst Simpsons comic ever. Once you start reading it, it gets boring, so take my advice, read everything else first, then come back to this one, since I lost enthusiasm after struggling to complete Krustonia for several days. That said, Homer's wresting days are really funny, the Smithers clones are strange, but somehow very entertaining. (Mr. Burns better watch out :) and Homer as Radioactive Man was great, especially to see Leon "Michael Jackson" Komposki back. I also liked the mini-Ned Flanders mystery, and the guide to comic book conventions. If it weren't for Krustonia, this book would be the perfect buy.
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Reviewed in the United States on July 30, 2000

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