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Description
iNOS Recombinant Rabbit mAb (S-2493-61)Product Specification Host Rabbit Antigen iNOS Synonyms Nitric oxide synthase, inducible; Hepatocyte NOS (HEP NOS); Inducible NO synthase (Inducible NOS; iNOS); NOS type II; Peptidyl cysteine S nitrosylase NOS2; NOS2A; NOS2 Immunogen Synthetic Peptide Location Cytoplasm Accession P35228 Clone Number S 2493 61 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | iNOS |
| Synonyms | Nitric oxide synthase, inducible; Hepatocyte NOS (HEP-NOS); Inducible NO synthase (Inducible NOS; iNOS); NOS type II; Peptidyl-cysteine S-nitrosylase NOS2; NOS2A; NOS2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P35228 |
| Clone Number | S-2493-61 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:100 | Ms |
Background
Inducible nitric oxide synthase (iNOS) is a ~131 kDa homodimeric flavo-hemoprotein that, upon transcriptional up-regulation by cytokines such as IFN-γ, TNF-α and LPS via NF-κB and STAT pathways, catalyzes the NADPH- and O₂-dependent five-electron oxidation of L-arginine to generate large, sustained fluxes of nitric oxide (NO) and citrulline; this Ca²⁺-independent, calmodulin-bound enzyme localizes in cytosol and peroxisomes of macrophages, hepatocytes, chondrocytes and many other cell types, where the produced NO acts as a microbicidal, tumoricidal and immunomodulatory radical that can react with superoxide to form peroxynitrite, leading to protein tyrosine nitration, lipid peroxidation and DNA damage, thereby contributing to antimicrobial defense, vasodilatory shock in sepsis, inflammatory arthritis, neurotoxicity and carcinogenesis, while its expression is tightly controlled by transcriptional, post-transcriptional (mRNA stability, microRNAs) and post-translational (ubiquitin-proteasomal degradation, phosphorylation) mechanisms to balance beneficial and cytotoxic NO levels.
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Exchange/Return Notes
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