SKU: 40529955124

BAFF Recombinant Rabbit mAb (S-2175-109)

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Description

BAFF Recombinant Rabbit mAb (S-2175-109)Product Specification Host Rabbit Antigen BAFF Synonyms Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator (BLyS); B cell activating factor; BAFF; Dendritic cell derived TNF like molecule; TNF and APOL related leukocyte expressed ligand 1 (TALL 1); CD257; BLYS; TALL1; TNFSF20; ZTNF4; TNFSF13B Immunogen Recombinant Protein Location Cell membrane Accession Q9Y275 Clone Number S 2175 109 Antibody Type Recombinant mAb Isotype IgG

Product Specification


Host Rabbit
Antigen BAFF
Synonyms Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator (BLyS); B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1 (TALL-1); CD257; BLYS; TALL1; TNFSF20; ZTNF4; TNFSF13B
Immunogen Recombinant Protein
Location Cell membrane
Accession Q9Y275
Clone Number S-2175-109
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu
Positive Sample HL-60, U-937
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:500-1:1000 Hu

Background

BAFF (B-cell activating factor), encoded by TNFSF13B and also known as BLyS or CD257, is a 285-aa type-II transmembrane glycoprotein of the TNF ligand superfamily produced by monocytes, dendritic cells, macrophages and activated T cells that can be cleaved to a soluble homotrimeric cytokine which, via engagement of three receptors—BAFF-R, TACI and BCMA—delivers survival and maturation signals to B cells, orchestrates T-cell co-stimulation, and drives class-switching and antibody production through NF-κB and PI3K/AKT pathways, while excess BAFF triggers B-cell hyperplasia and autoantibody formation, linking its overexpression to systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis and multiple myeloma, and making BAFF antagonism (e.g., belimumab) a validated therapeutic strategy.

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SKU: 40529955124

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4.0 ★★★★★
Based on 17 reviews
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Product Reviews
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Mainer
Birmingham, US
★★★★★ 5
My pick for Best YA from 2015
Format: Kindle
I don't usually like Westerns, but this historical novel reads like a racially diverse Little House on the Prairie. There's a touch of romance, but the most important relationship is the friendship between these two resourceful girls. The writing is superb with well developed characters, a fast pace and a fine sense of place and period (1849). Despite dealing with tough issues like murder, slavery and racism, it still manages to be a feel good story, appropriate for tweens as well as teens. The girl protagonists are 15 and 16 and the boys are a bit older. This debut tops my list of best YA from 2015 that I've read to date: http://blog.sarahlaurence.com/2015/12/best-ya-books-of-2015.html
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 18, 2015
M
Verified Purchase
Madeline M
Lexington, US
★★★★★ 3
Nice
Format: Kindle
There is some attempted sexual violence. Otherwise this is a good book for middle and high schoolers. Story of a Chinese American and African American girl on the run in the wild wild west.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 6, 2019
K
Verified Purchase
Kristy
Grantham, US
★★★★★ 4
... into YA Westerns and I have yet to be disappointed. Under a Painted Sky is a diverse
Format: Hardcover
Over the past year I have made a foray into YA Westerns and I have yet to be disappointed. Under a Painted Sky is a diverse, cultural infused tale of two girls, Our main character, Sam a Chinese, newly orphaned girl, teams up with Annamae (Andy), an African-America, runaway slave. Together they flee St. Joe, Missouri disguised as boys and begin on the Oregon Trail. They soon join three cowboys who help keep them safe and teach them how to survive. I think what I loved most about this book is how Lee was able to incorporate Sam's Chinese heritage and beliefs along with Andy's and intertwine all it beautifully into this richly told story. Sam's and Andy's friendship was also a highlight of the book. It caused for some great moments, some funny, many heartfelt, and I was glad to see such a positive example of female friendship in a YA novel. Although "girl disguised as boy" seem to be a common theme in YA westerns I did not mind it here and thought Sam's inner thoughts about the challenges of pretending to be a boy were hilarious. I think Lee struck the perfect balance between an adventure story, a coming of age tale, and portrait of what life could be like for minorities and females in the 1800s
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Reviewed in the United States on August 15, 2016
P
Verified Purchase
Pamela
Los Angeles, US
★★★★★ 5
A great BeeHive Award Winner!
Format: Kindle
This is a BeeHive Award winner for young adults! What a great read! It is a page turner, that's for sure. Two runaways--a slave and a Chinese girl--take to the trail West during the big Gold Rush. They meet up and join three young men traveling West to seek their fortunes. The catch? The girls are disguised as "boys!" The adventures begin! Fast paced book. Highly recommend it for young adults, but I really enjoyed it, too. Written well and in all situations, the characters were believable! I did make some predictions that, in fact, came true. Didn't ruin the story for me at all--only heightened my anticipation! Great read!
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Reviewed in the United States on October 27, 2016
A
Verified Purchase
AFSC
Omaha, US
★★★★★ 5
I absolutely loved everything about this story
Format: Kindle
I absolutely loved everything about this story. At first I was unsure of the time period, I've never been a huge western fan, but I'm so glad I picked this up. Not only were the historical details interesting, but the characters were timeless. Sammy was such a beautiful, courageous, complex main character, I couldn't help but root for her. The memories of her father and her connection to him through music was heartbreaking, and her heritage touched every facet of her life on the run. The family she formed with the cowboys and Andy was so genuine and real, and made me laugh in unexpected places. The action was fast paced and something was always happening, so it was hard to put down. Highly recommend this story for anyone who's a fan of adventure, strong female relationships, and romance. A++
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Reviewed in the United States on June 10, 2015

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