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Description
FGFR2b Recombinant Rabbit mAb, PBS Only (SDT-423-121)Product Specification Host Rabbit Antigen FGFR2b Synonyms FGFR2IIIb; Fibroblast growth factor receptor 2b; Fibroblast growth factor receptor 2IIIb Immunogen Synthetic Peptide Location Secreted, Cell membrane Accession P21802 3 Clone Number SDT 423 121 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample KATO III Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | FGFR2b |
| Synonyms | FGFR2IIIb; Fibroblast growth factor receptor 2b; Fibroblast growth factor receptor 2IIIb |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Cell membrane |
| Accession | P21802-3 |
| Clone Number | SDT-423-121 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | KATO III |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
FGFR2b is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR2b has important roles in embryonic development and tissue repair, especially bone and blood vessels. Recent studies have found that about 30% of patients overexpress FGFR2b protein, which may be used as a new biomarker and research target for gastric cancer.
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