SKU: 11840104710

Periostin Recombinant Rabbit mAb (S-2824-17)

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Description

Periostin Recombinant Rabbit mAb (S-2824-17)Product Specification Host Rabbit Antigen Periostin Synonyms PN; Osteoblast specific factor 2 (OSF 2); OSF2; POSTN Immunogen Recombinant Protein Location Secreted Accession Q15063 Clone Number S 2824 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample NCI H69 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.

Product Specification


Host Rabbit
Antigen Periostin
Synonyms PN; Osteoblast-specific factor 2 (OSF-2); OSF2; POSTN
Immunogen Recombinant Protein
Location Secreted
Accession Q15063
Clone Number S-2824-17
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample NCI-H69
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:2000 Hu

Background

Periostin is a 90-kDa secreted matricellular protein that consists of a typical signal peptide, an EMI domain, four tandem fasciclin-1 (FAS-1) domains implicated in cell adhesion and protein–protein interactions, and a C-terminal splice variant-rich domain that can generate six isoforms; it is predominantly expressed in collagen-rich connective tissues such as periodontal ligament, periosteum, heart valves, skin, and fibrotic lesions, where it is rapidly induced by TGF-β, IL-4/IL-13, mechanical stress or hypoxia and then deposited into the extracellular matrix via integrin-mediated binding to αvβ3, αvβ5 or α6β4 receptors on fibroblasts, thereby promoting collagen fibrillogenesis, cross-linking and tissue remodeling during embryonic development, wound healing, bone fracture repair, cardiac remodeling after myocardial infarction, and pathological fibrosis in asthma, atopic dermatitis, liver cirrhosis and various solid tumors, while also activating PI3K/Akt, FAK/Src, ERK and YAP/TAZ signaling pathways that enhance epithelial–mesenchymal transition, angiogenesis, cancer cell invasion, metastatic niche formation and chemoresistance, making it a valuable biomarker for disease progression and a potential therapeutic target for fibrosis and cancer.

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SKU: 11840104710

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