SKU: 14107086715

Mouse Anti-Human CD268 (BAFF Receptor) Antibody (S-4520)

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Description

Mouse Anti-Human CD268 (BAFF Receptor) Antibody (S-4520)Product Specification Host Mouse Antigen CD268 (BAFF Receptor) Synonyms Tumor necrosis factor receptor superfamily member 13C; B cell activating factor receptor; BAFF receptor (BAFF R); BLyS receptor 3; BAFFR; BR3; TNFRSF13C Location Membrane Accession Q96RJ3 Clone Number S 4520 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical

Product Specification


Host Mouse
Antigen CD268 (BAFF Receptor)
Synonyms Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor (BAFF-R); BLyS receptor 3; BAFFR; BR3; TNFRSF13C
Location Membrane
Accession Q96RJ3
Clone Number S-4520
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

CD268, also known as the B-cell Activating Factor Receptor (BAFF-R or BR3), is a type III transmembrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily that plays a pivotal role in B lymphocyte biology by serving as the primary high-affinity receptor for BAFF (BLyS). Predominantly expressed on the surface of mature and transitional B cells, CD268 is essential for B cell survival, maturation from the transitional to the follicular stage, and the maintenance of peripheral B cell homeostasis through the activation of key signaling pathways such as NF-κB (both canonical and non-canonical), PI3K/Akt, and MAPK. Upon binding to its ligand BAFF, CD268 prevents apoptosis by upregulating anti-apoptotic proteins like Bcl-2 and Mcl-1, thereby ensuring the longevity of the B cell pool; conversely, defects or deficiencies in CD268 signaling lead to a severe reduction in mature B cell numbers and impaired humoral immunity. Due to its critical function in B cell survival, CD268 is a significant therapeutic target in autoimmune diseases characterized by B cell hyperactivity, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, as well as in B cell malignancies, where blocking this receptor can effectively induce the depletion of pathogenic or malignant B cells.

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SKU: 14107086715

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4.5 ★★★★★
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lojo
Natrona Heights, US
★★★★★ 4
Cute but not hinged at arms
Color: Porcini Tortoise, Size: 52-17-140
They were cute. I didn’t like that they weren’t hinged. They were harder to open and close. I didn’t look for this feature before I purchased.
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Reviewed in the United States on February 3, 2026
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Amazon Customer
Lexington, US
★★★★★ 5
Anteojos modernos.
Color: Blush Tortoise, Size: Lens-52 Bridge-17 B-37.5 ED-56.1 Temple-140, Color: Blush Tortoise, Size: Lens-52 Bridge-17 B-37.5 ED-56.1 Temple-140
Mis lentes son muy cómodos, y me gustan como lucen, vienen sin medidas yo los adecué con mi Optometrista. Se aflojan con el tiempo, pero compré una pinza que ajusta los tornillos…realmente lucen como nuevos.
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Reviewed in the United States on January 20, 2026
G
Verified Purchase
ginger
Lake Worth, US
★★★★★ 5
The glasses are made well
Color: Pearl Brown Tort, Size: 53-16-135
The glasses fit well and are made well. They are Great value for the money.
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Reviewed in the United States on November 24, 2024
S
Verified Purchase
SirTW
San Leandro, US
★★★★★ 5
Sleek, upscale and supremely comfortable
Size: 9, Color: Cognac
I did not know that Marc Joseph makes hands free slip ins. I own four pair of Skechers, and I thought they were the only game in town. I decided that I wanted a pair of business casual pair of wingtips. I already own two pair of Skechers Mark Nason wingtips in blue and black nubuck, so I bought a pair of their cognac colored. Perfectly fine shoes, but when they arrived, I didn't like the color, so the search was on! I found these cognac-colored Mark Joseph's and hands down, they fit the bill for what I was looking for! I actually bought two more pair of Skechers in the brown family in the same oxford, elastic lace style: One pair of another style of their Mark Nason line and one pair of their Garza line. So now I am comparing three pair of Skechers to the Marc Joseph's. Obsessive, I know :). Luckily, I have a Skechers store near me for easy returns. The look I was going for is a sleek, business casual that I could dress up or down. Three things that I love about the Marc Joseph's are the beautiful cognac finish: the white yet lower profile soles and the more formal, narrower toe style. The MJ's nailed it with the color. They have a slightly darker, more lustrous and glossier look than the others. The color alone looks classier and pairs well with black pants which I wear for work almost every day. The white soles are exactly what I was looking for. The visible rise is probably about a third of the thickness of the others and are a much more subtle, classier look. They offset the cognac color nicely but are not that in your face, sneaker looking, thick white sole. When I was comparing them to the others right out of the box, I thought they would be too narrow and tight because they looked sleeker and narrower than the others. But they fit perfectly and were very comfortable right out of the box. Upon closer inspection and comparison, I realized the narrower, sleeker look is because the eyelets for the elastic shoelaces are closer together that give the illusion that the shoe is narrower. They compensate for what might create a tighter fit across the top of your foot with two stretchy "gores" they are called on either side of the upper part. The "slits" are nicely finished, and you can't see the stretchy part and add a nice design touch to the shoe. But between them and the elastic shoelaces, they must stretch just enough to make them extremely comfortable across the top. So, if you have a high instep/arch, they should accommodate it nicely. Last but not least, they are very comfortable shoes. I wear a size 8 1/2 to 9 and my foot is slightly on the wide side. I bought the size 9's and they fit perfectly. If you are between sizes or have wider feet, you may want to size up a half size. Because the Skechers have much thicker soles, they might be slightly more cushioned, but the MJ's are cushioned more than enough for my purposes and very comfortable. Plus, they actually just feel better on my feet. I can't speak to how durable they will be as I just got them, but so far, so good. So, there you have it. I rely on other people's reviews a lot when buying online, and especially for shoes. I know it's always a crap shoot, particularly when buying shoes online, so I hope this review helps. Everybody's feet are different, but I highly recommend these.
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Reviewed in the United States on March 15, 2025
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Ben
Alexandria, US
★★★★★ 5
Comfortable and look great!
Size: 10.5, Color: Cognac
Very comfortable, look nice, and slip on easily.
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Reviewed in the United States on June 4, 2026

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