SKU: 14593183190

Human ALPL Protein, His Tag

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Description

Human ALPL Protein, His TagProduct Specification Species Human Synonyms Alkaline phosphatase, tissue nonspecific isozyme, AP TNAP, TNAP, TNSALP, Alkaline phosphatase 2, Alkaline phosphatase liver bone kidney isozyme, Phosphoamidase, Phosphocreatine phosphatase, Akp 2, Akp2 Accession P09242 Amino Acid Sequence Protein sequence (P09242, Phe18 Ser502, with C His Tag)

Product Specification


Species Human
Synonyms Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNAP, TNSALP, Alkaline phosphatase 2, Alkaline phosphatase liver/bone/kidney isozyme, Phosphoamidase, Phosphocreatine phosphatase, Akp-2, Akp2
Accession P09242
Amino Acid Sequence

Protein sequence (P09242, Phe18-Ser502, with C-His Tag) FVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNLKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWAGS
Expression System HEK293
Molecular Weight Predicted MW: 55.3 kDa Observed MW: 65-90 kDa
Purity ＞95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Alkaline Phosphatase, Tissue-Nonspecific Isozyme (TNAP) is a ubiquitously expressed enzyme encoded by the ALPL gene. As the predominant alkaline phosphatase in humans, it is crucial for bone and tooth mineralization. TNAP hydrolyzes inorganic pyrophosphate, a potent mineralization inhibitor, and provides inorganic phosphate to promote hydroxyapatite crystal growth. Beyond its skeletal role, TNAP is also vital in neuronal development, vitamin B6 metabolism, and modulating intestinal inflammation. Mutations in ALPL cause hypophosphatasia, a metabolic bone disorder characterized by defective mineralization. Thus, TNAP serves as a central regulator of phosphate metabolism across multiple physiological systems.

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SKU: 14593183190

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4.8 ★★★★★
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Jj
Chelsea, US
★★★★★ 3
Not Hydrating Enough
Style: Updated Formula
Non greasy but is not moisturizing enough for my dry eczema prone skin.
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Reviewed in the United States on May 23, 2026
M
Verified Purchase
M. Gondek
Grantham, US
★★★★★ 5
Excellent for my sensitive skin and rosacea
Another excellent product from this brand. I have type 1 rosacea on my cheeks, even when I avoid triggers (like red wine, warm weather, etc.), and very sensitive skin overall. I've been using the cicalfate serum from this brand for the sensitivity, but it didn't help the redness. After two weeks of using this twice daily, I noticed a significant difference. After a month, I had no redness unless I encountered a trigger. Even then, the intensity of the redness seemed less. I tried going without this product for a month when the first bottle ran out, and sadly, the redness started coming back within a cycle of weeks. I've got this on auto-delivery now, along with the cicalfate serum. I never want to be without it!
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Reviewed in the United States on October 29, 2025
S
Verified Purchase
Sarah
Battle Creek, US
★★★★★ 5
Best moisturizer for sensitive skin
I have very sensitive skin and have tried many products over the years. This is by far the best daily moisturizer. I don’t wear makeup other than under eye concealer. This keeps my skin looking and feeling great. Not greasy. One bottle lasts about a month. I have probably bought this 10 times in the past year.
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Reviewed in the United States on February 27, 2026
S
Verified Purchase
Sarah
Lowell, US
★★★★★ 1
Not as good as the antirougeurs cream
I used to use the Antirougeurs cream and loved it but since they no longer make it, I had to switch. I have been using the redness expert cream for a week and it makes my face even redder. I also started to break out. The texture is good but I don’t think it works like the other cream.
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Reviewed in the United States on January 12, 2026
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Verified Purchase
DaytonaFan
Pawtucket, US
★★★★★ 5
Really helps with the redness
Years ago, my dermatologist recommended this line whenever I had a problem with redness. The redness occurs when I spend time outside, even with sunscreen & a hat. When I perspire it irritates my skin & poof, redness. I started using this, once I found it on Amazon, & this really helps to relieve the pain, discomfort & burning sensation. It has a cooling affect on your skin. Until I found this brand I simply suffered until the irritated skin healed. I apply this at night, especially after being outside & sweating & the redness is gone in the morning. I plan to use this until I no longer need it.
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Reviewed in the United States on November 20, 2024

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