SKU: 1465286056

Biotin Mouse Anti-Human CD170 (Siglec-5) Antibody (S-4097)

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Description

Biotin Mouse Anti-Human CD170 (Siglec-5) Antibody (S-4097)Product Specification Host Mouse Antigen CD170 (Siglec 5) Synonyms Sialic acid binding Ig like lectin 5; CD33 antigen like 2; Obesity binding protein 2 (OB BP2; OB binding protein 2); SIGLEC5; CD33L2; OBBP2 Location Membrane Accession O15389 Clone Number S 4097 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human Peripheral Blood cells Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical

Product Specification


Host Mouse
Antigen CD170 (Siglec-5)
Synonyms Sialic acid-binding Ig-like lectin 5; CD33 antigen-like 2; Obesity-binding protein 2 (OB-BP2; OB-binding protein 2); SIGLEC5; CD33L2; OBBP2
Location Membrane
Accession O15389
Clone Number S-4097
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human Peripheral Blood cells
Purification Protein G
Concentration 0.2 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD170 protein, also known as sialic acid-binding immunoglobulin-like lectin-5 (Siglec-5), is a type I transmembrane inhibitory receptor primarily expressed on myeloid cells (such as monocytes, macrophages, and neutrophils) and some B cells. It belongs to the immunoglobulin superfamily and the Siglec family. Its extracellular region contains an immunoglobulin-like domain that specifically recognizes and binds to sialylated glycans (commonly found on host cell surfaces), while its intracellular region contains an immunoreceptor tyrosine-based inhibitory motif (ITIM). Upon binding to sialylated self-ligands, the ITIM domain of CD170 becomes phosphorylated, recruiting and activating SH2 domain-containing protein tyrosine phosphatases (e.g., SHP-1/SHP-2), thereby transmitting potent inhibitory signals that negatively regulate the activation of myeloid cells, the production of inflammatory cytokines, and phagocytic functions. This mechanism plays a critical role in maintaining immune homeostasis and preventing excessive inflammatory responses against self-tissues. In pathological conditions, certain pathogens or tumor cells can evade immune surveillance by engaging CD170 through "molecular mimicry" or "decoy" mechanisms using surface sialylated glycans, thereby promoting persistent infection or tumor progression. Thus, CD170 is not only a key regulator of immune self-tolerance but also a potential target for infection immunotherapy and cancer immunotherapy. Modulating its function—for example, using monoclonal antibodies for blockade or agonism—may offer novel therapeutic strategies for autoimmune diseases, chronic inflammation, and cancer.

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SKU: 1465286056

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4.5 ★★★★★
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Verified Purchase
Davita Joy
Birmingham, US
★★★★★ 5
Excellent Buy
Color: Glue-Free Surface - Round, Set name: Set of 3 (S, M, XL)
We are in an ongoing process to reduce our dependence on plastics. These bamboo cutting boards are stunning, very well made, and easy to care for. I do recommend a wax to keep the surface shiny. Delighted with this purchase!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 29, 2026
J
Verified Purchase
Joy Livingwell
Alexandria, US
★★★★★ 5
Beautiful, high-quality, easy to clean, pleasant to use, no glue on food-facing surfaces
Color: Glue-Free Surface - Round, Set name: Set of 3 (S, M, XL)
I love these cutting boards! I've had them about 3 weeks, and use them multiple times per day. They are flat, rigid, lightweight, easy to handle, easy to clean, dry fast, and the range of sizes is great. Much better than the plastic cutting boards they replaced! The top and bottom of each cutting board is a single piece of bamboo. On the larger boards, one or more darker bands across the board show the bamboo's natural joints, called nodes. The boards are gorgeous to look at, a pleasure to work on, and nice to touch. (I LOVE the rounded edges.) Each board is a sandwich: top, core, bottom, with all joints on the edges of the board so no glued joint touches your food. The working surfaces smell only of bamboo. (If I sniff the edges where the glued joints are, I can faintly smell wood glue.) The boards are finished with odorless food-grade mineral oil. After 2 weeks of daily use and detergent scrubs, I started to see a slight dulling of the finish. I refreshed them using the same butcher block oil (odorless food-grade mineral oil) I use on wooden cutting boards. I made sure the bamboo was thoroughly dry, wiped on a small amount of oil, and let them dry overnight in my vertical cutting board rack. This returned the finish to like-new condition.
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Reviewed in the United States on February 6, 2025
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Verified Purchase
Love to Listen
Draper, US
★★★★★ 5
Customer Approved
Color: Glue-Free Surface - Round, Set name: Set of 3 (S, M, XL)
Very good. Thanks for the proper care instructions. Not too heavy and good sizing, A+.
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Reviewed in the United States on May 29, 2026
J
Verified Purchase
Jack Houghton
Pawtucket, US
★★★★★ 4
Nice bamboo cutting board set.
Color: Glue-Free Surface - Round, Set name: Set of 3 (S, M, XL)
So far have held up very well, and I feel better about not using plastic cutting boards. Good sizes, fairly easy to wash, but it’s a shame you can’t put them in the dishwasher. Overall a very good, sturdy product.
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Reviewed in the United States on March 9, 2026
M
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Michelle Thibault
Grantham, US
★★★★★ 5
Best cutting boards
Color: Glue-Free Surface - Round, Set name: Set of 3 (S, M, XL)
Fantastic boards, easy to wash, dry and oil. Don’t put in dishwasher as the wood may split. Hand wash and dry it right away and stand it on its side to dry.
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Reviewed in the United States on May 23, 2026

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