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Description
FOXP1 Recombinant Rabbit mAb (SDT-R053)Product Specification Host Rabbit Antigen FOXP1 Synonyms Forkhead box protein P1, MFH Immunogen N A Location Nucleus Accession Q9H334 Clone Number SDT R053 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IP, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as
Product Specification
| Host | Rabbit |
| Antigen | FOXP1 |
| Synonyms | Forkhead box protein P1, MFH |
| Immunogen | N/A |
| Location | Nucleus |
| Accession | Q9H334 |
| Clone Number | SDT-R053 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IP, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500-1:1000 | |
| ICFCM | 1:500 | |
| WB | 1:1000 | |
| ICC | 1:500 | |
| IP | 1:25 |
Background
The FOXP subfamily is defined by four members (FOXP1–FOXP4). FOXPs function as transcription factors and possess distinct transcriptional regulatory and DNA-binding domains. The N terminus of FOXPs contains a transcriptional repressor region with a zinc-finger/leucine zipper motif. The DNA-binding domain of FOXPs is uniquely positioned among forkhead proteins near the C terminus. FOXP1 is widely expressed in human tissues and regulates the development of many tissues, including heart, thymus, and lung. FOXP1-deficient embryos have severe defects in cardiac morphogenesis, including outflow tract septation and cushion defects, resulting in embryonic death.
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