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Description
CD68 Recombinant Rabbit mAb (S-3394)Product Specification Host Rabbit Antigen CD68 Synonyms Macrosialin; Gp110 Location Cell membrane Accession P34810 Clone Number S 3394 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Ms, Rt Positive Sample J774A. 1, RAW264. 7, mouse spleen, rat spleen Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | CD68 |
| Synonyms | Macrosialin; Gp110 |
| Location | Cell membrane |
| Accession | P34810 |
| Clone Number | S-3394 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Ms, Rt |
| Positive Sample | J774A.1, RAW264.7, mouse spleen, rat spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Ms |
| IHC-P | 1:250 | Ms, Rt |
| ICC | 1:500 | Ms |
| IF | 1:500 | Ms, Rt |
Background
CD68 is a heavily glycosylated, 110 kDa type I transmembrane glycoprotein of the lysosome-associated membrane protein (LAMP) family (also called LAMP-4) that is highly expressed on human monocytes, macrophages, osteoclasts, and other myeloid cells, where it predominantly localizes to lysosomes and endosomes and participates in phagocytosis, debris clearance, and inflammatory responses via its scavenger-receptor activity, while alternative splicing produces multiple isoforms and its presence on tumor cells and ability to bind selectins implicate it in metastasis, making it a widely used histological macrophage marker.
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