SKU: 1819938516

Biotinylated Nucleolin/NCL His&Avi Tag Protein, Human

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Description

Biotinylated Nucleolin/NCL His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms Protein C23 Accession P19338 1 Amino Acid Sequence Val2 Glu710 with His&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 90 100kDa (Reducing) Purity 85% by SDS PAGE Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Human
Synonyms Protein C23
Accession P19338-1
Amino Acid Sequence

Val2-Glu710 with His&Avi Tag at the C-Terminus

Expression System HEK293
Molecular Weight 90-100kDa (Reducing)
Purity >85% by SDS-PAGE
Conjugation Biotin
Tag Avi Tag, His Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, PH7.4, 5% trehalose

Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Reference

1.Yang L, Niu K, Wang J, Shen W, Jiang R, Liu L, Song W, Wang X, Zhang X, Zhang R, Wei D, Fan M, Jia L, Tao K. Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD. J Hepatol. 2024 Oct;81(4):651-666.
2.Thongchot S, Aksonnam K, Thuwajit P, Yenchitsomanus PT, Thuwajit C. Nucleolin-based targeting strategies in cancer treatment: Focus on cancer immunotherapy (Review). Int J Mol Med. 2023 Sep;52(3):81.

Background

Nucleolin (NCL) is a crucial multifunctional nucleolar protein in eukaryotic cells, possessing nucleo-cytoplasmic shuttling capability. Its three distinctive structural domains enable it to induce chromatin decondensation by binding to histone H1 and to specifically recognize RNA sequences (with higher affinity for 5'-UUAGGG-3' repeats than their DNA counterparts). This protein not only participates in fundamental biological processes such as ribosome biogenesis, pre-rRNA transcription and processing, and transcriptional elongation regulation, but is also extensively involved in cell proliferation, apoptosis regulation, and stress response. Under pathological conditions, through its roles in tumorigenesis and viral infection, nucleolin has emerged as a significant potential target for anti-tumor and anti-viral therapies.

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SKU: 1819938516

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4.8 ★★★★★
Based on 23 reviews
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Product Reviews
V
Verified Purchase
V.A.
Louisville, US
★★★★★ 5
Great addition to my sink!
Color: Black, Color: Black
This is a great sink organizer. I like a place for everything, and to hang up our dish cloth when done using it. We had a suction cup holder for that purpose but it broke several weeks ago. When this came in I noticed the 'washcloth bar' was just as another reviewer noted....pretty useless, unless you find a way to glue it down, so I chose to just toss that piece. We hang the cloth on the front fork piece, but that is also not secure and kept falling off. The simple solution for me was using some electrical tape to secure it. Not even noticeable and now works beautifully. Love the drainage with the sloped bottom, and having a spot for all the little thing we need handy at the sink. Highly recommend!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 21, 2025
A
Verified Purchase
Angelia
Carnegie, US
★★★★★ 4
Organizes & is inexpensive.
Color: Silver
Keeps items tucked & organized. Waterfall is not high enough off of sink if sink rises above counter more than an inch. Works fine for the price.
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Reviewed in the United States on May 17, 2026
T
Verified Purchase
TSheldon
West Palm Beach, US
★★★★★ 5
Convenient & organization
Color: Black, Color: Black
Size is Perfect for kitchen sink. It allowed for me to organize all the things laying around on the counter near faucet. Very functional and good value compared to others. The only thing that I would have preferred is to have 2 hooks for the Scrub daddy and lose the dishcloth hanger as I tend to to pull cloth and hanger off when I grab to clean or wipe something down.
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Reviewed in the United States on March 2, 2025
A
Verified Purchase
Amazon Customer
West Palm Beach, US
★★★★★ 5
Sturdy sponge and soap holder
Color: Black, Color: Black
Sturdy sponge holder, doesn’t slip, water drains from sponges and very easy to clean
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Reviewed in the United States on May 3, 2026
K
Verified Purchase
KL
Carnegie, US
★★★★★ 3
Works well after some super glue
Color: Black
Functional after slight modification. The towel bar, scrub daddy holder and brush holders will move and come out whenever you remove your towel/sponge/brushes. We super glued all the moving parts so they don't come apart during use and it was been working great after some adjustments. I would think other similar products would have the same issue. I would still recommend if you plan to glue all the moving parts together.
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Reviewed in the United States on June 29, 2025

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