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Description
NFKB1 Protein, HumanProduct Specification Species Human Synonyms Nuclear factor NF kappa B p105 subunit, DNA binding factor KBF1, EBP 1, Nuclear factor of kappa light polypeptide gene enhancer in B cells 1 Accession P19838 Amino Acid Sequence Met1 Gly434 Expression System E. coli Molecular Weight 50 55 kDa (Reducing) Purity >95% by SDS PAGE & HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 20mM Tris,
Product Specification
| Species | Human |
| Synonyms | Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
| Accession | P19838 |
| Amino Acid Sequence | Met1-Gly434 |
| Expression System | E.coli |
| Molecular Weight | 50-55 kDa (Reducing) |
| Purity | >95% by SDS-PAGE & HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 20mM Tris, 150mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Cell. 2008 Feb 8;132(3):344-62. |
Background
The NFKB1 gene, located on human chromosome 4q24, encodes the nuclear factor NF-κB p105 subunit (also termed EBP-1), a 105 kDa precursor protein that undergoes proteasome-mediated processing to generate the mature p50 subunit. NFKB1 functions as a pleiotropic transcription factor ubiquitously expressed across nearly all human cell types, serving as the terminal effector of diverse signal transduction cascades initiated by inflammatory cytokines, pathogens, oxidative stress, and mitogenic stimuli. The protein exhibits dual functional roles: (1) cytoplasmic sequestration of NF-κB complexes through its ankyrin repeat-rich C-terminal domain, and (2) generation of the DNA-binding p50 subunit that forms homodimers or heterodimers with Rel family members (e.g., p65/RELA) to regulate transcription of genes governing immune responses, inflammation, cell proliferation, survival, and apoptosis. NFKB1 activation involves IκB kinase (IKK)-mediated phosphorylation and degradation of inhibitory IκB proteins, enabling nuclear translocation of NF-κB dimers and binding to κB enhancer elements in target gene promoters.
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