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Description
Klotho Protein, MouseProduct Specification Species Mouse Synonyms Klotho; EC: 3. 2. 1. 31 Accession O35082 Amino Acid Sequence Ala35 Lys982, with C terminal His Tag Expression System HEK293 Molecular Weight 65, 75, 120 130 kDa (Reducing) Purity >85% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, 5% trehalose, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size
Product Specification
| Species | Mouse |
| Synonyms | Klotho; EC:3.2.1.31 |
| Accession | O35082 |
| Amino Acid Sequence | Ala35-Lys982, with C-terminal His Tag |
| Expression System | HEK293 |
| Molecular Weight | 65, 75, 120-130 kDa (Reducing) |
| Purity | >85% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, 5% trehalose, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 1997 Nov 6;390(6655):45-51. |
Background
Mouse Klotho (mKL) is a 1014-aa type-I trans-membrane glycoprotein of the glycosidase-1 super-family that is expressed mainly in distal convoluted tubule cells of the kidney, choroid plexus of the brain, and adrenal zona glomerulosa. A soluble 130-kDa form is generated by ADAM10/17 proteolytic shedding and circulates in plasma and CSF. Klotho functions as an obligate co-receptor for FGF23, thereby regulating phosphate and vitamin-D homeostasis; It also exhibits intrinsic β-glucuronidase activity that activates TRPV5/6 channels for renal Ca²⁺ reabsorption. Homozygous Klotho-deficient (kl/kl) mice on a mixed C57BL/6J, FVB, and C3H/J background develop a premature-aging phenotype—growth retardation, osteoporosis, arteriosclerosis, skin atrophy, emphysema, infertility, and death by 8–9 weeks. Conversely, transgenic over-expression extends lifespan and improves cognition, synaptic plasticity, and stress resilience.
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