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Description
IFN-α4/IFNA4 Protein, HumanProduct Specification Species Human Synonyms IFNA4, IFN alpha 4, IFN alpha 4, IFN alpha 4, IFN alpha4a, INFA4, interferon alpha 4, Interferon alpha 4B, Interferon alpha 76, Interferon alpha M1, interferon, alpha 4, MGC142200 Accession P05014 Amino Acid Sequence Cys24 Asp189, with C terminal 8*His
Product Specification
| Species | Human |
| Synonyms | IFNA4, IFN alpha 4, IFN-alpha 4, IFN-alpha-4, IFN-alpha4a, INFA4, interferon alpha-4, Interferon alpha-4B, Interferon alpha-76, Interferon alpha-M1, interferon, alpha 4, MGC142200 |
| Accession | P05014 |
| Amino Acid Sequence | Cys24-Asp189, with C-terminal 8*His CDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFGFPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKDGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 17-25kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. Pestka S, et al. (1987) Annu Rev Biochem. 56:727. 2. Fung, K.Y. et al. (2013) Science 339:1088. 3. Matsumiya, T. et al. (2007) J. Immunol. 179:4542. 4. Raj NB, et al. Identification of a novel virus-responsive sequence in the promoter of murine interferon-alpha genes. J Biol Chem. 1991 Jun 15, 266(17):11360-5. |
Background
The interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, and are classified based on their binding specificity to cell surface receptors. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha-subunit) and IFNAR2 (beta-subunit). This binding contributes to TNF-alpha induced signaling. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively. Interferon alpha (IFNa) shows significant biological activity in various cancers, particularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia. IFN-alpha 4 is promoted by interferon (IFN) regulatory factors (IRFs), especially IRF-1 and IRF-7. And it exhibits function by inhibiting virus RNA replication and enhances human natural killer cytotoxicity against virus.
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