Pay in installments of $67.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 12 - Aug 17
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
PTK7/CCK4 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms PTK7, CCK4, Tyrosine protein kinase like 7, Protein tyrosine kinase 7, Protein tyrosine kinase 7 Accession A0A2K5VNI5 Amino Acid Sequence Ala39 Thr712, with C terminal His Expression System HEK293 Molecular Weight 90 100kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0.
Product Specification
| Species | Cynomolgus |
| Synonyms | PTK7, CCK4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7, Protein-tyrosine kinase 7 |
| Accession | A0A2K5VNI5 |
| Amino Acid Sequence | Ala39-Thr712, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 90-100kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Lichtig H. et al. (2019) Ptk7 proteolytic fragment proteins function during early xenopus development. Dev Biol. 453 (1): 48-55. 2、Damelin M. et al. (2017) A ptk7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med. 9 (372): eaag2611. 3、Berger H. et al. (2017) Ptk7 faces the wnt in development and disease. Front Cell Dev Biol. 5: 31. |
Background
PTK7 comprises an extracellular region with seven immunoglobulin (Ig)-like loops, a transmembrane domain, and a cytosolic region containing a defective tyrosine kinase catalytic domain. Previous studies have reported that PTK7 functions as a co-receptor in the semaphorin/plexin signaling pathway, as well as in planar cell polarity and non-canonical Wnt signaling pathways during developmental processes. Additionally, PTK7 is associated with tumorigenesis. The expression of PTK7, which is upregulated in various malignancies, is negatively correlated with disease-free survival and/or overall survival in patients with cancer. PTK7 potentiates oncogenic signaling by functioning as a co-receptor for active RPTKs, such as FGFR1. The expression of PTK7 is also upregulated in endothelial cells, especially during tube formation.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.1 ★★★★★
Based on 26 reviews
Sort
Product Reviews
★★★★★ 5
Three froth/blend options, rechargeable, comes with container
Color: Rechargeable with Storage Box - Silver, Color: Rechargeable with Storage Box - Silver
I watch a gentleman online who always talks about how in his 40 years he didn’t know x, y, z, and ends with “ain’t no way.” He made this 3-ingredient — 4 with ice— iced coffee, and used a handheld frother, so after shopping for ingredients, I went in search of a frother. What I liked about this one is that it’s not battery operated, but instead is rechargeable. It comes with three attachment, one of which I can use for cake batter, whipping up eggs, making homemade whipped cream, and also sauces and gravy. It also has a case so I am storing it with my coffee paraphernalia. It has three settings and I used the high setting. As you can see it really froths up the ingredients. I’m very pleased with my purchase and thought about all the times I need a slurry of water and cornstarch to thicken soups and stews. I don’t know the charge life yet, but so far, so good. What you see in the cup is 2 tablespoons of sweetened condensed milk, 3 teaspoons of instant espresso, and 2 ounces of water. Then you add the ice and your creamer, half-and-half, or barista lover’s oat milk, and you’re done. Not too bad, as my grandpa used to say.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 9, 2026
★★★★★ 5
Great product
Color: Rechargeable with Storage Box - Black
It’s great! Very powerful, even on low speed. Mixes fiber, and powdered mix-ins very well as well as frothing milk. Nice sturdy little case to keep the components in. Stays charged for a long time.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 5, 2026
★★★★★ 5
Easy to use, perfect small mixer for mornings
Color: Rechargeable with Storage Stand and Box - Black
Comes charged and charges quickly when needed, love the stand and case for the extra attachments, easy to use and clean
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 27, 2026
★★★★★ 5
Best Hand-Held Frother EVER
Color: Rechargeable with Storage Stand and Box - Black
I have had many hand-held frothers over the years; hand-held as well as counter top. None of them have really given me the froth that I want which is dense foam to the point that it almost forms "peaks" and needs to be spooned into my coffee. Additionally, the one that I always went back to (hand-held) only lasted for 3-6 months at best before breaking and sometimes it lasted only a few weeks. Additionally, it drained batteries to the point they needed to be replaced every 2-3 weeks. The Circle Joy DOES make thick, dense froth (I use very cold skim milk on the high speed), has 3 speeds and is rechargeable so no more battery issues. Once I froth the milk, I pop it in the microwave for 40 seconds or so to heat/warm it up. It also comes with an attachment for beating eggs as well as an attachment for stirring in protein powders. I don't need the egg beater and I use the low speed to mix in chocolate collagen powder. I just got this frother so reliability is yet to be proven but I figure at $20.00 even if it needs to be replaced every six months ... it is still a winner.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 8, 2026
★★★★★ 4
Works well, worth buying.
Color: Rechargeable with Storage Stand and Box - Black
Works really well. I wish the attachments were easier to get off without feeling like you are going to break them. I use a butter knife to pry it off carefully. I like having the case too, it works well if you need to travel with it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 31, 2026
recommand products
Enrico Rava: Smiling in Hollywood & Mario Rusca/Riccardo Fiorav - COMPACT DISCS
23.99
Carolyn Arends: Feel Free - COMPACT DISCS
20.99
Stargazers: South of the Border/Singles 1953-58 - COMPACT DISCS
26.99
Marek Weber: Vol. 2-Musicale - COMPACT DISCS
13.99
Primus: Green Naugahyde - COMPACT DISCS
19.99