SKU: 21184259108

KCNQ2 Recombinant Rabbit mAb (S-3465-49)

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Description

KCNQ2 Recombinant Rabbit mAb (S-3465-49)Product Specification Host Rabbit Antigen KCNQ2 Synonyms Potassium voltage gated channel subfamily KQT member 2; KQT like 2; Neuroblastoma specific potassium channel subunit alpha KvLQT2; Voltage gated potassium channel subunit Kv7. 2 Immunogen Synthetic Peptide Location Cell membrane Accession O43526 Clone Number S 3465 49 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample mouse brain, rat brain

Product Specification


Host Rabbit
Antigen KCNQ2
Synonyms Potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Voltage-gated potassium channel subunit Kv7.2
Immunogen Synthetic Peptide
Location Cell membrane
Accession O43526
Clone Number S-3465-49
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt
Positive Sample mouse brain, rat brain
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt

Background

The KCNQ2 protein is a voltage-gated potassium channel α-subunit, encoded by the KCNQ2 gene, that plays a critical role in regulating neuronal excitability throughout the central nervous system. Predominantly expressed in the brain, KCNQ2 primarily forms heterotetrameric complexes with KCNQ3 subunits to constitute the M-current (IKM), a slowly activating, non-inactivating potassium current that acts as a crucial brake on repetitive neuronal firing by stabilizing the resting membrane potential and preventing excessive depolarization. Functionally, this current is activated at subthreshold membrane potentials and is essential for controlling action potential threshold, firing frequency, and burst accommodation in neurons. Clinically, mutations in KCNQ2 are associated with a spectrum of epileptic disorders, ranging from benign familial neonatal epilepsy (BFNE) to severe developmental and epileptic encephalopathies (DEE) characterized by refractory seizures, intellectual disability, and neurodevelopmental impairment. The KCNQ2 channel serves as the primary pharmacological target for retigabine (ezogabine), an antiepileptic drug that activates the channel by inducing a conformational shift favoring the open state, thereby enhancing the M-current and reducing neuronal hyperexcitability. Structurally, KCNQ2 contains six transmembrane domains (S1-S6), with the S4 segment functioning as the voltage sensor and the S5-S6 loop forming the channel pore, while intracellular domains mediate subunit assembly, trafficking, and calmodulin-dependent regulation of channel gating kinetics.

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SKU: 21184259108

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4.0 ★★★★★
Based on 14 reviews
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RVRW
Charlottesville, US
★★★★★ 3
Pretty Good But Not Perfect!
Size: 28'' X 34''
I have been using two of these frames for my miniature poodle puppy for almost a month now and while they are useful, they could be improved. The size of the frames are great for our miniature size poodle puppy and the Amazon pads that fit the frames absorb well without leaking underneath. The grips on the bottom of the frame keep it in place so it does not slide across floor. The frame hinges in the center so you can easily carry it through doorways. I am in my 60's so it is nice to be able to carry it to my work table in order to change pads while standing up. My 4 month old 10 pound puppy can make a dinner plate size circle of pee onto the pad first thing in the morning. 4 large pees are easily held by the pee pads before needing to change it but we prefer to change the pads more often for sanitary reasons. Not sure if you have a very large breed dog that these would work for you. Our puppy likes going on these without hesitation so they are comfortable for him to walk around on and turn to find just the right spot! Compared to other brands I have looked at this is a great value for money and worth a try to help with potty training your pup. Our puppy sleeps in an X-pen inside of our home at night and when we are gone so these help with keeping the pads where we want them. We have two - one inside X-pen and one by door where we are training puppy to go outside. These frames are nice in appearance and seem like they will last but they are a little awkward to use compared to another brand I purchased which was more durable and easier to change pad. I ended up with these because other brands do not offer such a large size (28 x 34). Our main complaints about these frames are: 1. The top frame is hinged and a little wobbly to manuever over the edges of the pee pads. Another brand, while a bit smaller, has a solid one piece frame that goes over entire pad in one step. This frame requires a three step process of laying pad down, pulling edges out flat and placing one side of frame down and then repeating on other side. There is usually a bit of adjustment that needs to be done and so requires opening and closing the frame again for adjustments. 2. The Amazon pee pads that fit this frame hold the pee well without leaking but have very thin tissue paper like edges (blue) that do not extend out far enough to make capturing the edges of the pee pad under the frame very easy to maneuver. It would be a game changer if the pads were made at least 1" bigger around length and width so edges are firmly held in place. 3. Our tiny 10 pound poodle pup is able to easily dig out edges of pad and tear it up. Not as bad as a loose pad by any means, but blue edges are exposed at side centers where frame hinges and there is no cover of edges (unlike a one piece frame) and the blue color seems to attract him. He can dig and loosen pad on any side because there is no way to hide and hold down all of the blue edges of pee pad. I am still using these to potty train and, as I said earlier, these are way better than loose pee pads. I may shop for even larger size pee pads in the future to better lock down all of the edges without so much difficulty.
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Reviewed in the United States on May 5, 2026
J
Verified Purchase
Just a simple guy.
Carnegie, US
★★★★★ 4
Good product for dog training.
Size: 22'' X 22''
Work for the most part. Dogs will chew on it so wipe it down with dawn dish soap. Hard to clean where it clips down.
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Reviewed in the United States on March 13, 2026
F
Verified Purchase
Freedom
Belleville, US
★★★★★ 5
Saving My Floors
Size: 28'' X 34'', Size: 28'' X 34''
Omg, what a game changer. My pups like to destroy the pads whenever they get the chance to. With this they still try but never succeed. I will say that it can be a little sturdier as the handles are a little flimsy, but I manage and it does the job. It's very easy to use when I change the pads and I use 2 pads for coverage. I just placed it where I usually place their pads and it fits right in the spot. They are trained to go outside but on rainy days this comes in handy. To save my floors it's definitely worth the money spent.
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Reviewed in the United States on April 26, 2026
V
Verified Purchase
VegasHawkeye
San Leandro, US
★★★★★ 5
Picky dog approved!
Color: S6-muti-color, Color: S6-muti-color
I have wasted so much money on dog balls that they won't even pick up! They finally were obsessed with the Kong rubber green/blue or red/blue ones, but they're $3+. each, and they break from the dogs squishing it. I honestly had zero expectations on these, and they BOTH picked them up on the first throw! That's huge!! Seem to work fine in the ChuckIt. As for the squeaker, at first I was like "Oh nooooo." when they both loudly started! Much to my (and my neighbors') happiness, the squeakers stopped working after a couple minutes. 🤣
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Reviewed in the United States on February 2, 2025
W
Verified Purchase
William Lovelace
Cuba, US
★★★★★ 5
Great dog toys
Color: S6-muti-color
These are long lasting, durable dog toys. My dogs love the squeak sound.
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Reviewed in the United States on May 23, 2026

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