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Description
Invivo anti-Mouse CD8α Recombinant mAbProduct Specification Host Rat Antigen CD8 Synonyms Lyt 2 Location Cell membrane Accession P01731 Clone Number S R540 Antibody Type Rat mAb Isotype Rat IgG2a,k Application in vivo CD8+ T cell depletion Reactivity Ms Purification Protein G Concentration 5 mg ml Endotoxin <2EU mg Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no preservative Stability & Storage 12 months from date of receipt reconstitution, 2
Product Specification
| Host | Rat |
| Antigen | CD8α |
| Synonyms | Lyt-2 |
| Location | Cell membrane |
| Accession | P01731 |
| Clone Number | S-R540 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2a,k |
| Application | in vivo CD8+ T cell depletion |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Background
CD8α encodes the CD8 alpha chain of the αβT cells, proposed as a quantifiable indicator for CD8+ CTL recruitment or activity assessments and a robust biomarker for responses to anti-PD-1/PD-L1 therapy. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
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