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Ships within 48 hours · Estimated delivery Aug 15 - Aug 20
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Description
Mouse Anti-Human CD85j Antibody (S-3041)Product Specification Host Mouse Antigen CD85j Synonyms Leukocyte immunoglobulin like receptor subfamily B member 1; LIR 1; Leukocyte immunoglobulin like receptor 1; CD85 antigen like family member J; Immunoglobulin like transcript 2 (ILT 2); Monocyte macrophage immunoglobulin like receptor 7 (MIR 7); ILT2; LIR1; MIR7; LILRB1 Location Cell membrane Accession Q8NHL6 Clone Number S 3041 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity
Product Specification
| Host | Mouse |
| Antigen | CD85j |
| Synonyms | Leukocyte immunoglobulin-like receptor subfamily B member 1; LIR-1; Leukocyte immunoglobulin-like receptor 1; CD85 antigen-like family member J; Immunoglobulin-like transcript 2 (ILT-2); Monocyte/macrophage immunoglobulin-like receptor 7 (MIR-7); ILT2; LIR1; MIR7; LILRB1 |
| Location | Cell membrane |
| Accession | Q8NHL6 |
| Clone Number | S-3041 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood cells |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD85j, also known as LILRB1 or ILT2, is a 110 kDa transmembrane glycoprotein belonging to the leukocyte immunoglobulin-like receptor (LILR) family. It is an inhibitory receptor broadly expressed on leukocytes, including B cells, monocytes, subsets of NK cells, memory/effector CD8+ T cells, gamma δ T cells, and monocyte-derived dendritic cells. CD85j recognizes a wide range of classical HLA-class I allelic variants, as well as non-classical molecules such as HLA-F and HLA-G, by binding to the conserved α3 domain. Additionally, it binds to the human cytomegalovirus-encoded MHC class I homologue UL18. The engagement of CD85j by its ligands induces inhibitory signals that downregulate immune responses, including the inhibition of antigen-induced proliferation and activation of CD8+ T cells, CD4+ T cells, NK cells, and gamma δ T cells. On dendritic cells, ligation of CD85j inhibits the production of cytokines like IL-10, IL-12p70, and TGF-beta and protects from Fas-mediated apoptosis.
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Exchange/Return Notes
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