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Description
Tim23 Recombinant Rabbit mAb (S-2241-105)Product Specification Host Rabbit Antigen Tim23 Synonyms Mitochondrial import inner membrane translocase subunit Tim23; TIM23; TIMM23 Immunogen Synthetic Peptide Location Mitochondrion Accession O14925 Clone Number S 2241 105 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HepG2, SK OV 3, Jurkat, MCF7, SK BR 3, NIH 3T3, mouse heart, PC 12, rat heart, COS 7 Predicted Reactivity Bv, Or, Xe Purification
Product Specification
| Host | Rabbit |
| Antigen | Tim23 |
| Synonyms | Mitochondrial import inner membrane translocase subunit Tim23; TIM23; TIMM23 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | O14925 |
| Clone Number | S-2241-105 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HepG2, SK-OV-3, Jurkat, MCF7, SK-BR-3, NIH/3T3, mouse heart, PC-12, rat heart, COS-7 |
| Predicted Reactivity | Bv, Or, Xe |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
Background
Tim23 is an essential subunit of the TIM23 translocase in the mitochondrial inner membrane, where it serves as both a structural scaffold and a voltage-gated component that recognizes presequences of incoming precursor proteins in the intermembrane space, triggers channel opening in response to membrane potential, and—together with Tim17, Tim44, mtHsp70 and other motor proteins—forms a highly conserved multiprotein machine that imports ~1,000 matrix-destined and inner-membrane proteins from the cytosol into mitochondria, thereby undergirding organellar biogenesis and cellular energy metabolism.
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