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Description
Invivo Anti-Mouse CD200 (OX2) Recombinant mAb (S-R739)Product Specification Host Rat Antigen CD200 (OX2) Synonyms OX 2 membrane glycoprotein; MRC OX 2 antigen; Mox2 Location Cell membrane Accession O54901 Clone Number S R739 Antibody Type Rat mAb Isotype Rat IgG2a,k Application FCM, in vivo CD200 blockade, in vitro CD200 blockade Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 5 mg ml Endotoxin <2EU mg Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rat |
| Antigen | CD200 (OX2) |
| Synonyms | OX-2 membrane glycoprotein; MRC OX-2 antigen; Mox2 |
| Location | Cell membrane |
| Accession | O54901 |
| Clone Number | S-R739 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2a,k |
| Application | FCM, in vivo CD200 blockade, in vitro CD200 blockade |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Endotoxin | <2EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
|
Dilution
| application | dilution | species |
| FCM | 1:5000 | Ms |
Background
CD200 (OX2) protein is a type-1 membrane glycoprotein belonging to the immunoglobulin superfamily, widely distributed on various cell types including thymocytes, neurons, endothelial cells, and immune cells such as macrophages and dendritic cells. It plays a crucial role in immune regulation by interacting with its receptor CD200R, which is highly expressed on myeloid cells and some lymphoid cells. The CD200-CD200R interaction inhibits inflammatory responses, promotes immune tolerance, and helps maintain tissue homeostasis. In cancer, CD200 is often overexpressed on tumor cells, contributing to immune evasion by suppressing anti-tumor immune responses. Additionally, elevated levels of soluble CD200 (sCD200) in serum are associated with adverse tumor prognosis in several cancers.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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