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Description
Human Stratifin/14-3-3 sigma Protein, His TagProduct Specification Species Human Synonyms 14 3 3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1 Accession P31947 Amino Acid Sequence Protein sequence (P31947, Met1 Ser248, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1 |
| Accession | P31947 |
| Amino Acid Sequence | Protein sequence (P31947, Met1-Ser248, with C-His Tag) MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGGEAPQEPQS |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 29.5 kDa Observed MW: 30 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
14-3-3 protein sigma (SFN), also known as Stratifin, is a crucial member of the 14-3-3 family. It functions as a phospho-serine/phospho-threonine binding protein that regulates a wide array of cellular processes, including cell cycle progression, apoptosis, and stress response. A key and well-characterized role of 14-3-3 sigma is its involvement in the DNA damage checkpoint, where it is transcriptionally activated by p53 and helps arrest the cell cycle. It often acts as a tumor suppressor, and its expression is frequently lost in various cancers through epigenetic silencing. Furthermore, 14-3-3 sigma is implicated in epithelial cell biology and is a significant marker in cancer research and diagnosis.
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