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Description
TGF beta 1 Recombinant Rabbit mAb (S-3204)Product Specification Host Rabbit Antigen TGF beta 1 Synonyms Transforming growth factor beta 1 proprotein; TGFB; TGFB1 Location Secreted Accession P01137 Clone Number S 3204 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HeLa, A549, HL 60, SH SY5Y, NIH 3T3, RAW264. 7, mouse spleen, C6, rat spleen Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | TGF beta 1 |
| Synonyms | Transforming growth factor beta-1 proprotein; TGFB; TGFB1 |
| Location | Secreted |
| Accession | P01137 |
| Clone Number | S-3204 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, A549, HL-60, SH-SY5Y, NIH/3T3, RAW264.7, mouse spleen, C6, rat spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
Transforming Growth Factor-beta 1 (TGF-β1) is a multifunctional 25 kDa homodimeric cytokine that belongs to the TGF-β superfamily and is secreted by virtually all somatic cells as a large latent complex bound to latency-associated peptide and latent TGF-β binding protein; upon activation by proteases or integrins it signals through a heteromeric receptor complex of TβRII and ALK5 (TβRI) serine/threonine kinases to phosphorylate Smad2/3, which then complex with Smad4 to regulate transcription of hundreds of genes that orchestrate pleiotropic effects ranging from embryogenesis, extracellular matrix deposition, immune suppression and wound healing to cell cycle arrest, apoptosis, and epithelial-mesenchymal transition, with dysregulation implicated in fibrosis, cancer, and autoimmune disease.
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