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Description
Runx1 Recombinant Rabbit mAb (S-959-64)Product Specification Host Rabbit Synonyms Runt related transcription factor 1, Acute myeloid leukemia 1 protein, Core binding factor subunit alpha 2 (CBF alpha 2), Oncogene AML 1, Polyomavirus enhancer binding protein 2 alpha B subunit (PEA2 alpha B; PEBP2 alpha B), SL3 3 enhancer factor 1 alpha B subunit, SL3 AKV core binding factor alpha B subunit Immunogen Synthetic Peptide Location Nucleus Accession Q01196 Clone Number S 959 64 Antibody Type
Product Specification
| Host | Rabbit |
| Synonyms | Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2 (CBF-alpha-2), Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit (PEA2-alpha B; PEBP2-alpha B), SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q01196 |
| Clone Number | S-959-64 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC, ICFCM, IP |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:500 | |
| ICFCM | 1:5000 | |
| IP | 1:50 |
Background
Runx1 is a crucial transcription factor that binds to the core elements of many enhancers and promoters, regulating the expression of specific genes. This protein plays a pivotal role in cellular development, particularly in the development of hematopoietic stem cells. RUNX1 interacts with CBFβ (core-binding factor β) to form a set of transcription factors, and this interaction is essential in the development of neurons and hematopoietic stem cells. However, when CBFβ undergoes translocation, it can form a fusion protein CBFβ-SMMHC that abnormally binds tightly to RUNX1, participating in the pathogenesis of acute lymphocytic leukemia (ALL). Therefore, the RUNX1−CBFβ interaction is also considered an important target for cancer treatment. Furthermore, research on RUNX1 protein has revealed its association with a range of cancers, particularly leukemia. Chromosome translocations involving the RUNX1 gene have been clearly linked to several types of leukemia.
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