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Description
SLC7A11 & SLC3A2 Flag-His Tag Protein, Human (Detergent)Product Specification Species Human Synonyms SLC7A11 & SLC3A2 Accession Q9UPY5P08195 Concentration 0. 38mg ml by Nanodrop Amino Acid Sequence The SLC7A11 protein carries a Flag tag at the N terminus. The SLC3A2 protein carries a polyhistidine tag at the C terminus. Expression System HEK293 Molecular Weight 50 kDa&75 kDa Purity 90% by SDS PAGE &90% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tags & Cleavage sites 3C Physical Appearance
Product Specification
| Species | Human |
| Synonyms | SLC7A11 & SLC3A2 |
| Accession | Q9UPY5、P08195 |
| Concentration | 0.38mg/ml by Nanodrop |
| Amino Acid Sequence | The SLC7A11 protein carries a Flag tag at the N-terminus.The SLC3A2 protein carries a polyhistidine tag at the C-terminus. |
| Expression System | HEK293 |
| Molecular Weight | 50 kDa&75 kDa |
| Purity | ＞90% by SDS-PAGE &＞90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tags & Cleavage sites | 3C |
| Physical Appearance | Liquid with detergent |
| Storage Buffer | 25 mM Tris，ph8.0, 150 mM NaCl，0.1%LMNG，0.01%CHS. |
| Stability & Storage | ·6 months from date of receipt, -60 to -80 °C as supplied. |
| Reference | 1. Parker J L, Deme J C, Kolokouris D, et al. Molecular basis for redox control by the human cystine/glutamate antiporter system xc−[J]. Nature communications, 2021, 12(1): 7147. |
Background
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death characterized by an accumulation of lipid-derived reactive oxygen species (ROS). The small-molecule compound erastin induces ferroptosis via inhibiting the cysteine-glutamate antiporter system, which consists of two subunits, namely the SLC7A11 and SLC3A2, respectively). Recent studies have shown that SLC7A11 regulates ferroptosis in liver fibrosis, cardiomyopathy, and numerous other pathophysiological processes. The complex formed by SLC7A11 and SLC3A2 has also been suggested as a possible therapeutic target for cancer, as it is overexpressed in a wide variety of cancer types; moreover, inhibiting the system impairs cystine uptake, causing an accumulation of ROS and suppressing tumor growth. To counteract elevated levels of reactive oxygen species in cancerous cells system xc- is frequently upregulated, making it an attractive target for anticancer therapies. Overall, the SLC7A11 & SLC3A2 complex is a key player in multiple physiological processes and has significant potential as a therapeutic target for various diseases. The product of SLC7A11 & SLC3A2 complex may improve the development of its drug discovery.
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