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Description
HDAC1 Recombinant Rabbit mAb (SDT-310-72)Product Specification Host Rabbit Antigen HDAC1 Synonyms Histone deacetylase 1, HD1, Protein deacetylase HDAC1 Immunogen Synthetic Peptide Location Nucleus Accession Q13547 Clone Number SDT 310 72 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu, Ms, Rt Predicted Reactivity Bv Purification Protein A Concentration 0. 05 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | HDAC1 |
| Synonyms | Histone deacetylase 1, HD1, Protein deacetylase HDAC1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q13547 |
| Clone Number | SDT-310-72 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.05 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | |
| IHC-P | 1:200 | |
| ICC | 1:50 | |
| ICFCM | 1:50 | |
| IP | 1:25 |
Background
HDAC family has four subclasses including I, II, III and IV. Histone deacetylase 1 (HDAC1) is a unique member of the classes I HDACs that has been shown to be involved in gene transcription, transcriptional regulation, cell cycle progression and developmental events by controlling both enzyme activity and epigenetics of key proteins [PMID: 16289629]. HDAC1 is the most abundant member of the class I HDACs in pulmonary endothelial cells [PMID: 34264338], regulating the enzymatic activity and epigenetics of key proteins to adapt to external stimuli. It can efficiently decrotonylate this relatively less abundant histone modification [PMID: 29317660].
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