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Description
Wnt3a Recombinant Rabbit mAb,PBS Only (SDT-3300)Product Specification Host Rabbit Antigen Wnt3a Synonyms Protein Wnt 3a; WNT3A Location Secreted Accession P56704 Clone Number SDT 3300 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Ms Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt reconstitution, 4 C as supplied Dilution application dilution species IHC P 1:
Product Specification
| Host | Rabbit |
| Antigen | Wnt3a |
| Synonyms | Protein Wnt-3a; WNT3A |
| Location | Secreted |
| Accession | P56704 |
| Clone Number | SDT-3300 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:200 | Ms |
Background
Wnt3a is a secreted, palmitoleated glycoprotein of ~39 kDa that acts as a principal ligand for canonical Wnt signaling; upon binding to Frizzled and LRP5/6 co-receptors it triggers a β-catenin–dependent cascade leading to TCF/LEF-mediated transcription of genes that govern embryonic axis formation, neural crest specification, self-renewal of hematopoietic and intestinal stem cells, and osteoblast differentiation, while its dysregulation drives colorectal, breast and hematologic malignancies, and recombinant Wnt3a is widely used in vitro to expand organoids and maintain pluripotency.
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