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Description
Human SOX-9, His TagProduct Specification Species Human Synonyms S0X 9 Accession P48436 Amino Acid Sequence Protein sequence(P48436, His169 Pro300 with C 10*His) MHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLPPGGGGSHHHHHHHHHH Expression System E. coli Molecular Weight Theoretical: 16. 1kDa Actual: 20kDa Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical
Product Specification
| Species | Human |
| Synonyms | S0X-9 |
| Accession | P48436 |
| Amino Acid Sequence |
Protein sequence(P48436, His169-Pro300 with C-10*His)
|
| Expression System | E.coli |
| Molecular Weight | Theoretical: 16.1kDa Actual: 20kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
12 months from date of receipt, -20 ℃ to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
SOX-9 is a protein that in humans is encoded by the SOX9 gene. It is expressed by proliferating but not hypertrophic chondrocytes that is essential for differentiation of precursor cells into chondrocytes and, with steroidogenic factor 1, regulates transcription of the anti-Müllerian hormone (AMH) gene. The Sox-9 protein has also been implicated in both initiation and progression of multiple solid tumors. Its role as a master regulator of morphogenesis during human development makes it an ideal candidate for perturbation in malignant tissues. Specifically, Sox9 appears to induce invasiveness and therapy-resistance in prostate,[16] colorectal, breast and other cancers, and therefore promotes lethal metastasis. Many of these oncogenic effects of Sox9 appear dose dependent.
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