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Description
Alexa Fluor® 488 Rat Anti-Mouse CD43 Antibody (S-R588)Product Specification Host Rat Antigen CD43 Synonyms Leukosialin; B cell differentiation antigen LP 3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48 (Ly 48); Sialophorin; Spn Location Membrane Accession P15702 Clone Number S R588 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage
Product Specification
| Host | Rat |
| Antigen | CD43 |
| Synonyms | Leukosialin; B-cell differentiation antigen LP-3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48 (Ly-48); Sialophorin; Spn |
| Location | Membrane |
| Accession | P15702 |
| Clone Number | S-R588 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD43, also known as leukosialin or sialophorin, is a highly glycosylated type I transmembrane protein predominantly expressed on most hematopoietic cells, with the exception of resting B cells and erythrocytes. It belongs to the sialomucin superfamily and is one of the largest cell-surface molecules, extending approximately 45 nm from the cell surface. The protein consists of a heavily glycosylated extracellular region, a transmembrane helix, and a small cytoplasmic region. CD43 plays a significant role in immune function, particularly in T-cell activation and proliferation, and is involved in both cell adhesion and cell activation processes. It is actively excluded from the immunological synapse during T-cell activation, a process that requires interactions with ezrin-radixin-moesin (ERM) proteins. Additionally, CD43 has been shown to regulate T helper type 2 differentiation and can act as a co-stimulatory molecule for T-cell activation.
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